Reduced-antigen-content diphtheria-tetanus-acellular pertussis (dTpa) vaccine, Boostrix™, is indicated for booster vaccination of children, adolescents and adults. The original prefilled disposable dTpa syringe presentation was recently replaced by another prefilled-syringe presentation with latex-free tip-caps and plunger-stoppers. 671 healthy adolescents aged 10-15 years who had previously re...

We conducted 3 phase III, randomized, open-label, clinical trials assessing the safety, reactogenicity (all studies), immunogenicity (Primary vaccination study) and persistence of immune responses (Booster study) to the combined diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b vaccine (DTPa-IPV/Hib) in Chinese infants and toddlers. In the Pilot study (NCT00964028...

OBJECTIVES In 1998 the World Health Organization (WHO) recommended the inclusion of Haemophilus influenza type B (Hib) conjugate vaccines in infant immunization programs, whenever in accordance with national priorities. GlaxoSmithKline Biologicals has developed a new pentavalent combined diphtheria-tetanus-whole cell pertussis-hepatitis B/Hib (DTPw-HB/Hib) vaccine containing 5 microg of polyrib...

Introdoction: Hepatitis B comprises one of the major health problems worldwide. Health Care Workers (HCW) are a group at risk for Hepatitis B Virus (HBV) infection. The aim of this study is Management of nonresponder health care workers to hepatitis B routine vaccination. Methods: In a descriptive-analytical study conducted in the Department of infectious diseases in the University Of Medical S...

Value of booster immunisation with influenza vaccine in patients undergoing haemodialysis The public health authorities ofmost Western countries recommend annual influenza vaccination for some patients, including those with end stage renal disease.' Patients on haemodialysis, however, show impaired antibody responses after a single influenza vaccination, which may result in insufficient protect...

Introduction: The AbC-19™ lateral flow immunoassay (LFIA) performance was evaluated on plasma samples from a SARS-CoV-2 vaccination cohort, WHO international standards for anti-SARS-CoV-2 IgG (human), individuals ≥2 weeks infection of RT-PCR confirmed genetic variants, as well microorganism serology. Methods: Pre-vaccination to three post-booster were collected cohort 111 patients (including cl...

To reduce pertussis disease burden new vaccination strategies are considered in many countries. Since not only health benefits, but also economical aspects play a role when introducing new vaccinations, we estimated medical costs of pertussis in the Netherlands. Besides, we retrospectively performed a cost-utility analysis of the preschool booster introduced in 2001. Our results show that annua...

ride IgG responses are shown in the table. The proportions of children who had antibody titres below the minimum protective level of 0.15ìg/ml before receiving their booster dose at 1 year of age was higher than previously reported with the more extended primary immunisation schedule. The mean increase in antibody titre after administration of the booster dose was 803-fold (95% confidence inter...

From December 1998 through February 1999, a study was conducted in a Brucella-infected bison herd to evaluate the safety of booster vaccination of adult bison (Bison bison) with 6 x 10(9) colony forming units (CFU) of Brucella abortus strain RB51 (SRB51) that had previously been vaccinated as yearlings with 1 x 10(10) CFU of SRB51. Abortions or other adverse effects were not observed after SRB5...