The excess release of mediators can cause clinical features such as pruritus, flushing, nausea, vomiting, diarrhoea, abdominal pain, vascular instability and anaphylaxis. Also, complications may arise when mast cells accumulate in the skin, gastrointestinal tract, bone marrow, liver, spleen, and lymph nodes. [2] The clinical features of systemic mastocytosis are caused by accumulation of clonal...

changes here described from the appearance of secondary neoplasm, particularly neuroblastoma, may be difficult, and the diagnosis may only become clear with evolution of more typical radiological appearances. Eversole, Holman, and Robinson in 1957 described focal resorption of cortical bone as an early microscopical feature in the evolution of infantile cortical hyperostosis. The relative vascu...

The excess release of mediators can cause clinical features such as pruritus, flushing, nausea, vomiting, diarrhoea, abdominal pain, vascular instability and anaphylaxis. Also, complications may arise when mast cells accumulate in the skin, gastrointestinal tract, bone marrow, liver, spleen, and lymph nodes. [2] The clinical features of systemic mastocytosis are caused by accumulation of clonal...

Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells and accounts for about 3 - 5% all cell neoplasms including bone extramedullary tumors. Plasmacytomas are more predominant in males who the 5th – 6th decade. It most often located head neck region. usually affects upper respiratory tract 80% cases 15% spread to cervical lymph nodes. They pres...

BackgroundExtraskeletal osteosarcoma (ESOS) is a rare, aggressive, malignant high grade mesenchymal neoplasm, predominantly occurs in lower extremities and rarely involves the visceral organs. Till now only 6 cases of mesenteric ESOs have been reported in the literature. ESOS affects older age group than osteosarcoma of bone. ESOS has poor outcome with high rate of mortality around 7080%. Our b...

this case report presents a combination of surgical and prosthetic solutions applied to a case of oral implant rehabilitation in post-oncologic reconstructed mandible. bone resection due to surgical treatment of large mandibular neoplasm can cause long-span defects. currently, mandibular fibula free flap graft is widely considered as a reliable technique for restoring this kind of defect. it re...

BACKGROUND Klippel-Trenaunay syndrome is a non-heritable venous malformation with bone and soft tissue hypertrophy and cutaneous nevi. CASE CHARACTERISTICS Neonate with Klippel Trenaunay syndrome born to a mother with past history of Gestational trophoblastic neoplasm. OBSERVATION Antenatally, a fetal vascular malformation was identified ultrasonologically at 29 weeks gestation. Acute myelo...

Plasma cell neoplasm is characterized by a monoclonal neoplastic proliferation of plasma cells and solitary plasmocytoma of bone (SPB) is a localized form. It usually occurs in vertebrae and secondarily in long bones. Its presence in mandible is extremely rare event. A 48-year-old man consulted to our clinic with a chief complaint of pain in his mandible. Radiography revealed a destructive lesi...