The study is designed to evaluate the effect of aqueous extract P. lanceolata plant, as well know drug CCl4 on formation micronucleus in vivo 48 female albino mice. In mice were separated into eight groups treated intraperitoneally for seven day first group Negative control, second positive control( 0.02%), third (250 mg/kg), fourth (500 fifth (CCl4 0.02%) plus sixth seventh mg/kg) and eighth 0...

When a bone marrow erythroblast develops into a polychromatic erythrocyte, the main nucleus is extruded; any micronucleus that has been formed may remain behind in the otherwise anucleated cytoplasm. Visualisation of micronuclei is facilitated in these cells because they lack a main nucleus. An increase in the frequency of micronucleated polychromatic erythrocytes in treated animals is an indic...

In the present study, we have evaluated the protective effect of vitamin E (VE) against adriamycin (AD) and cyclophosphamide (CP) induced genotoxicity using chromosome aberration and micronucleus assays in Wistar rat bone marrow cells. The level of lipid peroxidation product malondialdehyde, the activity of antioxidant enzymes

Hymenaea courbaril L., popularly known as jatobá, is a plant species that grows in the forests of South America. The species has been used for culinary purposes and in folk medicine to treat arthritis and inflammations. Due to the increasing use of this plant globally, the present study aimed to evaluate the toxic, genotoxic, recombinogenic, and antigenotoxic effects of H. courbaril sap (Hycs) ...

Euphorbia nivulia is a tall deciduous tree belonging to the family Euphorbiaceae. It is mainly found in India and is reported to have tremendous therapeutic potential. Herbal medicine may cause damage to genetic material which may lead to an increased risk of cancer and other diseases. Hence, it becomes important to assess the genotoxicity assessment of herbal medicines. The present study was c...

Arsenic is a human skin, lung, and urinary bladder carcinogen, and may act as a cocarcinogen in the skin and urinary bladder. Possible modes of action of arsenic carcinogenesis/cocarcinogenesis include oxidative stress induction and inhibition of DNA damage repair. We investigated the effects of arsenic in drinking water on DNA damage repair in urinary bladder transitional cells and on micronuc...

OBJECTIVES The aim of this study was to investigate the genotoxic effects of indium trichloride (InCl(3)·4H(2)O; InCl(3)) using the in vivo bone marrow micronucleus test and the in vitro CHL/IU cell micronucleus test. METHOD BALB/c mice were administered a single intraperitoneal (i.p.) injection of InCl (3) at a dose 0.625, 1.25, 2.5, 5, or 10 mg/kg b.w. The frequency of micronuclei, the rati...

Arisolochiae species plants containing aristolochic acids I and II (AA I and AA II) are well known to cause aristolochic acid nephropathy (AAN). Recently, there are various approaches to use AAs-containing herbs after the removal of their toxic factors. However, there is little information about genotoxicity of Arisolochiae manshuriensis Kom. (AMK) per se. To obtain safety information for AMK, ...

The genotoxic effects of 4 organophosphorous pesticides, i.e. ekatin, fenitrothion, methylparathion and phorate, were examined employing the micronucleus test in bone marrow cells of the rat. Methylparathion and phorate were found to be mutagenic, while ekatin was weakly mutagenic. The frequency of micronuclei induction by fenitrothion did not differ significantly from that noticed in negative ...

Commonly used guidelines for the management of human immunodeficiency virus (HIV) infection (highly active antiretroviral therapy, HAART) include drug combinations such as tenofovir disoproxil fumarate (TDF) + lamivudine (3TC) and combivir [zidovudine (AZT) + 3TC] + efavirenz (EFV). These combinations may enhance the genotoxic effects induced by such drugs individually, since the therapy requir...