Myeloablative preconditioning using irradiation is the most commonly used technique to generate rodents having chimeric bone marrow, employed for the study of bone marrow-derived cell accumulation in the healthy and diseased central nervous system. However, irradiation has been shown to alter the blood-brain barrier, potentially creating confounding artefacts. To better study the potential of b...

BACKGROUND Clinical trials report improvements in function and perfusion with direct injection of bone marrow cells into the hearts of patients with ischemic cardiomyopathy. Preclinical data suggest these cells improve vascular density, which would be expected to decrease fibrosis and inflammation. OBJECTIVES The goal of this study was to test the hypothesis that bone marrow stem cells (CD34+...

AIM Evaluate intra-articular injection of bone marrow concentrate (BMC), followed by platelet-rich plasma (PRP) injection at 8 weeks follow-up in moderate/severe osteoarthritis. DESIGN Single center, retrospective Case Series (n = 125). METHODS Bone marrow was aspirated/concentrated using a standardized technique. Patients received a single intra-articular injection of BMC, with follow-up i...

it is estimated that annually 10 million people are affected by traumatic brain injury and it is one of the major causes of death and disability in accidents. studies have shown the potential therapeutic value of neural stem cell therapies. also, neural stem cell motility and migration to the site of injury has a great regeneration value of the damaged tissues. extracellular and intracellular f...

background: bone marrow-derived mesenchymal stem cells (bmmscs) transplantation has been considered as a promising milestone in liver fibrosis treatment. however, low amounts of homing are a major obstacle. we aimed to investigate the role of melatonin pretreatment in bmmsc homing into experimental liver fibrosis. methods: bmmscs were obtained, grown, propagated and preconditioned with 5 µm mel...

Heavily irradiated mice have been protected from otherwise lethal bone marrow damage by intravenous injection of rat bone marrow."'S5'14 It has been amply demonstrated that the radio-protection offered by the rat bone marrow is actually due to myelopoietic repopulation of the mouse marrow cavity by rat marrow precursor cells."",'8 13 l Mice given supralethal irradiation plus rat bone marrow hav...

The author studied the hematopoietic disturbances of rabbit induced by saponin injection and drew the following conclusions: 1) By saponin injection, the structure of bone marrow is disintegrated and hematopoietic cells are released into the circulating blood forming extramedullary hematopietic foci mainly in liver and spleen. The main attacking point of saponin should be RES. Recovery of hemat...