Purpose: The effects of 2 graft materials, -tricalcium phosphate (Cerasorb) alone and a combination of Cerasorb and platelet-rich plasma (PRP), on the bone regeneration process were evaluated in the canine mandible. Materials and Methods: The mandibular premolars of 12 beagle dogs were surgically removed. The extraction sockets were filled with Cerasorb on the control side and a mixture of Cera...

Osteopontin (OPN) was expressed in murine wild-type osteoclasts, localized to the basolateral, clear zone, and ruffled border membranes, and deposited in the resorption pits during bone resorption. The lack of OPN secretion into the resorption bay of avian osteoclasts may be a component of their functional resorption deficiency in vitro. Osteoclasts deficient in OPN were hypomotile and exhibite...

The use of titanium mesh for localized alveolar ridge augmentation was evaluated by clinical, radiographic, laboratory, and histologic-histomorphometric evaluation. Seventeen patients participated in this study. All patients required localized alveolar ridge augmentation before placement of dental implants. An equal mixture of autogenous bone graft and inorganic bovine mineral (Bio-Oss) was use...

Bone microstructure has usually been assessed by obtaining samples invasively and analyzing them with conventional histomorphometric methods. Improvements in high-resolution image acquisition systems have enabled non-invasive assessment of bone morphology and a more precise 3-D evaluation by means of "virtual biopsies", permitting bone assessment in regeneration or remodeling processes. Among o...

introduction : efforts are being made to improve the efficacy of biomaterials used as bone substitutes for bone regeneration in the oral and maxillofacial region. graft materials have been recently produced in iran; however, studies are required to confirm their efficacy. this study aimed to compare the histomorphometric results of using mineralized allografts produced by the hamanandsaz baft k...

A robust method for inducing bone-formation without an autograft has not been established. Currently, both platelet-rich plasma (PRP) and bone morphogenetic protein (BMP) have been widely investigated for their clinical use in such cases. However, their synergistic effect is still controversial and previously shown diversity of this effect depends on various factors such as the bone substitutes...

Previous studies have shown a generalised increase in bone mass in patients with osteoarthritis (OA). Using molecular histomorphometry, this study examined the in vivo expression of mRNA encoding bone anabolic factors and collagen type I genes (COL1A1, COL1A2) in human OA and non-OA bone. Bone samples were obtained from the intertrochanteric (IT) region of the proximal femur, a skeletal site di...

BACKGROUND Decalcified freeze-dried bone allograft (DFDBA) may have the potential to enhance bone formation around dental implants. Our aim in this study was the evaluation and comparison of two types of DFDBA in treatment of dehiscence defects around Euroteknika(®) implants in dogs. METHODS In this prospective clinical trial animal study, all mandibular premolars of three Iranian dogs were e...

AIMS To define and group static and dynamic iliac crest histomorphometric parameters in women with established osteoporosis. METHODS Iliac crest biopsy specimens from 146 white women were sectioned undecalcified and examined using image analysis. RESULTS Five distinct groups were defined on the basis of histomorphometric changes in cell function: group 1, decreased osteoblastic and osteocla...

BACKGROUND Rheumatic diseases are associated with an increased fracture risk. The tissue level characteristics of the bone involvement in children have not been well elucidated. Our objectives were to describe the bone micro-architectural characteristics in children with rheumatic diseases on chronic glucocorticoids, and to determine associations between micro-architectural findings with clinic...