On entering the tissues, infiltrating autoreactive T cells must be reactivated locally to gain pathogenic activity. We have previously reported that, when activated by Toll-like receptor 3 (TLR3) and TLR4 ligands, retinal astrocytes (RACs) are able to function as antigen-presenting cells to re-activate uveitogenic T cells and allow responder T cells to induce uveitis in mice. In the present stu...

Streptococcus pneumoniae (pneumococcus) has remained a persistent cause of invasive and mucosal disease in humans despite the widespread use of antibiotics and vaccines. The resilience of this organism is due to its capacity for adaptation through the uptake and incorporation of new genetic material from the surrounding microbial community. DNA uptake and recombination is controlled by a tightl...

B-cell-biased lymphoid progenitors (BLPs) and Pre-pro B cells lie at a critical juncture between B cell specification and commitment. However, both of these populations are heterogenous, which hampers investigation into the molecular changes that occur as lymphoid progenitors commit to the B cell lineage. Here, we demonstrate that there are PDCA-1(+)Siglec H(+) plasmacytoid dendritic cells (pDC...

Pregnancy is a high-risk factor for foodborne pathogen Listeria monocytogenes (Lm), which causes abortion, premature birth, or stillbirth. The primary route of Lm transmission oral hence intestinal epithelial barrier crossing prerequisite systemic spread. Intestinal crossing, in part, attributed to the interaction adhesion protein (LAP) with its cognate receptor, Hsp60. In recent study, we show...

Graph-Based label propagation algorithms are popular in the state-of-the-art semi-supervised learning research. The key idea underlying this algorithmic family is to enforce labeling consistency between any two examples with a positive similarity. However, negative similarities or dissimilarities are equivalently valuable in practice. To this end, we simultaneously leverage similarities and dis...

incomplete adaptation of stainless steel crown margins leads to microleakage. the aim of this study was to evaluate the effect of tooth preparation on microleakage of stainless steel crowns (sscs) placed on mesiodistally reduced primary mandibular first molars.in this in vitro study, 60 primary mandibular first molars with reduced mesiodistal dimension were selected. pulp cavities were filled w...

Shallow parsing is one of many NLP tasks that can be reduced to a sequence labeling problem. In this paper we show that the latent-dynamics (i.e., hidden substructure of shallow phrases) constitutes a problem in shallow parsing, and we show that modeling this intermediate structure is useful. By analyzing the automatically learned hidden states, we show how the latent conditional model explicit...

Shallow parsing is one of many NLP tasks that can be reduced to a sequence labeling problem. In this paper we show that the latent-dynamics (i.e., hidden substructure of shallow phrases) constitutes a problem in shallow parsing, and we show that modeling this intermediate structure is useful. By analyzing the automatically learned hidden states, we show how the latent conditional model explicit...

La liseta Mugil curema está entre las principales especies que explota la pesquería artesanal en costa mexicana del Océano Pacífico. Abordar aspectos reproductivos de por zona pesca reducirá el sesgo evaluación estado sus poblaciones. El objetivo presente estudio fue describir ciclo reproductivo y estimar algunos parámetros biológicos dos sitios Baja California Sur. Mensualmente, se muestreo ca...