.......................................................................................................... xi 1. ENDOTHELIUM-DEPENDENT VASODILATION: A REViEW ..................................... 1 What is the Nature of the Cholinergic, Endothelium-Dependent Response? 1 Endothelium-Derived Relaxing Factor ................................................. 2 Influence of Contractile Agent and Ton...

Purpose. To characterize developing retinal blood vessels with vascular markers and to relate the histochemical profile of maturing vessels to morphologic stages in retinal vascular development. Methods. Vessels were examined in frozen and paraffin-embedded retinas and in wholemounts of Macaca monkeys ranging in age from fetal day 75 (F75) to adulthood. Endothelial cells were visualized immunoh...

Age is one of the most important risk factors for cardiovascular disease. For example, a 30-year-old male smoker with untreated hypertension, diabetes, dyslipidemia, and a strong family history of premature coronary heart disease (CHD) would have a 10-year coronary heart disease event rate of only 16% (“intermediate risk”) by Framingham criteria; however, given exactly the same risk profile for...