Coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory coronavirus 2 (SARS-CoV-2). Among hospitalized patients, many have developed typical manifestations of sepsis-like cold extremities, weak peripheral pulses or metabolic acidosis, indicating microcirculation dysfunction.1 Microvascular dysfunction has been reported in sepsis2, 3 and could be partly red blood ...

Sickle-cell anaemia (SCA) is an inherited blood disorder exhibiting heterogeneous cell morphology and abnormal rheology, especially under hypoxic conditions. By using a multiscale red blood cell (RBC) model with parameters derived from patient-specific data, we present a mesoscopic computational study of the haemodynamic and rheological characteristics of blood from SCA patients with hydroxyure...

Microfabrication of polydimethylsiloxane (PDMS) devices has provided a new set of tools for studying fluid dynamics of blood at the scale of real microvessels. However, we are only starting to understand the power and limitations of this technology. To determine the applicability of PDMS microchannels for blood flow analysis, we studied white blood cell (WBC) margination in channels of various ...

We present an experimental study of the rheology and structure a confined suspension deformable particles flowing in quasi-two-dimensional Poiseuille flow. Thanks to precise microfluidic viscosimetry technique combined with measurements concentration profiles, our provides first confirmation {with three-dimensional particles} strong relationship between structuring effects rheology, previously ...

Computational blood flow simulations over patient-specific image-based three dimensional domains under personalized flow conditions have been extensively used to investigate associations between flow characteristics and aneurysm initiation, progress and rupture. Although it is widely accepted that the wall shear stress is associated to those processes, there is still no agreement about what str...

Plasma proteins and lipid profile influence whole blood fluidity through changes in plasma viscosity, red cell aggregability and deformation. In diseases like Cushing syndrome (CS) and diabetes mellitus (DM) plasma concentrations of fibrinogen, cholesterol, and triglycerides are increased, and, thus, blood rheology might be affected. Our aim was to determine parameters of blood fluidity in 26 d...

At the cellular scale, blood fluidity and mass transport depend on the dynamics of red blood cells in blood flow, specifically on their deformation and orientation. These dynamics are governed by cellular rheological properties, such as internal viscosity and cytoskeleton elasticity. In diseases in which cell rheology is altered genetically or by parasitic invasion or by changes in the microenv...

The present review presents basic concepts of blood rheology related to vascular diseases. Blood flow in large arteries is dominated by inertial forces exhibited at high flow velocities, while viscous forces (i.e., blood rheology) play an almost negligible role. When high flow velocity is compromised by sudden deceleration as at a bifurcation, endothelial cell dysfunction can occur along the ou...