discrimination between iron deficiency (ida) anemia and β-thalassemia trait (β-tt) is a time consuming and costly problem. because, they have approximate similar effects on routine blood test indices, in some cases, the complementary tests, which are expensive and time consuming, would be needed for differentiate the anemia. complete blood count (cbc) is a fast, inexpensive, and accessible medi...

We used a unique animal model, the hypotransferrinemic (Htx) mouse, to examine the role of transferrin (Tf) in gastrointestinal iron uptake. Despite the absence of Tf, Htx animals hyperabsorb iron. Transfusion of red blood cells sufficient to normalize the hematocrit and reticulocyte count resulted in a return of iron absorption to normal values. These studies indicate that Tf does not play an ...

A animal model was developed whereby reticulocyte-rich blood was introduced into normal rats by exchange transfusion. Measurements of plasma iron turnover was made at similar plasma iron concentrations before and after exchange transfusions. High reticulocyte blood obtained from animals rendered iron deficient by diet or by treatment with phenylhydrazine resulted in a mean increase of 86% in in...

BACKGROUND & OBJECTIVES Regular blood donation can lead to pre-clinical iron deficiency as well as iron deficiency anaemia. There is a need to increase the national voluntary blood donation for safe blood supply. However, there is paucity of data in the country regarding impact of regular voluntary blood donation on iron status of donors. Hence, iron stores were evaluated by serum ferritin esti...

Objective(s): Nowadays, examining the toxicity of nanoparticles including the synthesized and functionalized iron nanoparticles using methods like green synthesis is highly considered, due to their increasing usage in various fields of medicine, biology, industrial, and pollution removal. Hence, in this study, the toxicity of the zero valent iron nanoparticles synthesized by plant-Myrtus commun...

Purpose Retinal iron accumulation is observed in a wide range of retinal degenerative diseases, including AMD. Previous work suggests that Müller glial cells may be important mediators of retinal iron transport, distribution, and regulation. A transgenic model of Müller cell loss recently demonstrated that primary Müller cell ablation leads to blood-retinal barrier leakage and photoreceptor deg...

in this study the iron status of pregnant women in two different socio-economic groups and also the effect of multigravidity on iron status of the mothers were investigated. blood samples were with drawn from 165 mothers (91 from farah and 74 from missaghieh maternity hospital) immediately after delivery and hemoglobin, hematocrit, serum iron, total iron-binding capacity (tibc) and total protei...

To the Editor: Over the past 3 decades, the routine use of erythropoeisis-stimulating agents (ESA) has enabled the correction of anemia in most patients with end-stage renal disease (ESRD), reducing the need for blood transfusions and improving the quality of life of severely anemic patients. Almost all ESA-treated hemodialysis patients receive parenteral iron to ensure sufficient available iro...