Confronted by the contents of this issue, the reader may be surprised, even dismayed, by the preponderance of papers on blood coagulation, and he may protest that the usual balance between the branches of pathology is also upset. (This will be rectified in future issues.) He may feel that the importance of this subject to him, as a clinical pathologist, is unlikely to justify the effort require...

The conversion of prothrombin to thrombin constitutes a major step in blood coagulation. Aside from its important hemostatic function, the reaction has broad biological significance since it is one of the few examples of protein-protein and proteinion interaction with profound physiological as well as pathological effects. As an archetype of such reactions, clearer delineation of the nature of ...

This report describes some of the accomplishments of Oscar Ratnoff, one of the leaders in the field of coagulation research. His career exemplifies the attributes of an accomplished physician–scientist who has excelled in basic and clinical research, teaching and training, and clinical practice. Dr Ratnoff’s discovery of Hageman and Fitzgerald factors and his development of the waterfall hypoth...

EDITOR: Thromboelastograph (TEG) displays the viscokinetic properties [1] of the clot formed, which in turn reflects the functions of different factors involved in the coagulation process [2] and also the interaction between these factors. TEG is considered to be better than the conventional coagulation tests [3] and is becoming more popular among perioperative clinicians in managing coagulopat...

INTRODUCTION I N 1945, Nolf1 described a serum constituent, distinct from thrombin, which was capable of furthering coagulation. More recently, Ware et al. reported a substance, designated serum Ac globulin, which activates the conversion of prothrombin to thrombin by thromboplastin. Independently, Owren5 discovered a new clotting factor, ‘ ‘Factor VI,’ ‘ which arises during coagulation, speeds...

CONTEXT Herbal remedies are used to treat a large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly by disruption of the coagulation cascade. OBJECTIVE The compiling of plants investigated for effects on the coagulation cascade. METHODS Information was withdrawn from Google...