Bullous pemphigoid (BP) is by far the most common autoimmune blistering dermatosis that mainly occurs in the elderly. The BP180 is a transmembrane glycoprotein, which is highly immunodominant in BP. The structure and location of BP180 indicate that it is a significant autoantigen and plays a key role in blister formation. Autoantibodies from BP patients react with BP180, which leads to its degr...

OBJECTIVE To determine whether paper tape prevents foot blisters in multistage ultramarathon runners. DESIGN Multisite prospective randomized trial. SETTING The 2014 250-km (155-mile) 6-stage RacingThePlanet ultramarathons in Jordan, Gobi, Madagascar, and Atacama Deserts. PARTICIPANTS One hundred twenty-eight participants were enrolled: 19 (15%) from the Jordan, 35 (27%) from Gobi, 21 (16...

Delayed post‐burn blistering is an interesting and unusual phenomenon which has received little attention in the literature.[1,2] We herein report a case of a 20‐year‐old man who presented to the dermatology outpatient department with complaints of recurrent, apparently spontaneous blistering, occurring over a post‐ burn scar. The patient had sustained a thermal burn with accidental spillage of...

The impact of pill organizers on pill taking was determined in the Trial of Antioxidant Vitamins C and E (TRACE) Study, a factorial trial of vitamin C and vitamin E supplementation in 184 individuals. Participants were recruited in 1996–1997 and randomized to one of two groups (pill organizer or no organizer) and to one of four supplement groups for 2 months. The pill count (observed/expected X...

OBJECTIVE Blister-like aneurysms are small hemispherical bulges that usually originate from the anteromedial wall of the distal internal carotid artery and cause significant subarachnoid hemorrhage. It is very important to recognize this novel lesion as a different type of aneurysm than ordinary berry aneurysms. CASE DESCRIPTION We report the case of a 43-year-old man who underwent a diagnost...

The O-GlcNAc transferase Eogt modifies EGF repeats in proteins that transit the secretory pathway, including Dumpy and Notch. In this paper, we show that the Notch ligands Delta and Serrate are also substrates of Eogt, that mutation of a putative UDP-GlcNAc binding DXD motif greatly reduces enzyme activity, and that Eogt and the cytoplasmic O-GlcNAc transferase Ogt have distinct substrates in D...

the current study assesses the root causes of hydrogen blisters on low strength carbon steel equipment. for this purpose, some experiments including hardness test, non-destructive test (ndt), metallography, and fractograpghy are conducted. the microstructure of two blisters is assessed by means of optical microscopy and scanning electron microscopy (sem). the microstructural studies show that t...