In this study, matrix-type transdermal patches of glibenclamide were developed using a combination hydrophilic and hydrophobic polymers for investigating the efficacy carriers. A cellulose derivative, HPMC E50, was used as matrix-forming polymer, Eudragit RS 100 polymer. The solvent casting technique employed to develop blend patch formulation chloroform methanol solvent. No drug–polymer intera...

Nanophase separation into hydrophobic and hydrophilic domains in commercial perfluorosulfonic acid polymers promotes high conductivity by forming proton-conductive channels within a matrix. To transfer this beneficial phase to phosphonic functionalized ionomers, we combine phosphonated polypentafluorostyrene flexible polyoctylstyrene di-block-co-polymer. We introduce stepwise approach, includin...

PVDF-based membranes with low-fouling and high permeability properties were developed by blending poly(vinylidene fluoride) (PVDF) poly(2-methoxyethyl acrylate) (PMEA), a polymer, via non-solvent induced phase separation (NIPS). Since PMEA suppresses protein adsorption is insoluble in water, the homopolymer was used as an additive. Consequently, transparent dope solutions containing 15 wt% PVDF...

INTRODUCTION Blend sign has been recently described as a novel imaging marker that predicts hematoma expansion. The purpose of our study was to investigate the prognostic value of CT blend sign in patients with ICH. OBJECTIVES AND METHODS Patients with intracerebral hemorrhage who underwent baseline CT scan within 6 hours were included. The presence of blend sign on admission nonenhanced CT w...

BACKGROUNDS Intracranial post-operative re-haemorrhage is an important complication in patients with hypertensive intracerebral haemorrhage (ICH). The purpose of the present study was to determine the value of the computed tomography (CT) blend sign in predicting post-operative re-haemorrhage in patients with ICH. METHODS A total of 126 patients with ICH were included in the present study. Al...