BACKGROUND Bladder pain associated with interstitial cystitis and painful bladder syndrome (IC/PBS) is frequently excruciating and intractable. The use of onabotulinumtoxinA (BoNT-A) for relief of this type of bladder pain has not been well described. OBJECTIVES To evaluate the efficacy and safety of intravesical BoNT-A injection for treatment of IC/PBS refractory to conventional treatment. ...

Onset of cystitis in patients receiving immuno-chemotherapeutic agents by intravesical instillation for non-muscle invasive transitional cell carcinoma of the bladder or after radiotherapy for prostatic cancer is frequent and problematic, since it responds poorly and slowly to the usual symptomatic treatments. This iatrogenic complication often means that cancer therapy has to be interrupted on...

5 INVESTIGATION OF AN ACUTE ROLE FOR NON-NEURONAL CELLS IN PELVIC PAIN AND BLADDER DYSFUNCTION IN A NOVEL MOUSE MODEL OF EXPERIMENTAL AUTOIMMUNE CYSTITIS (EAC). Bicer F, Huang W, Daneshgari F, Hanna-Mitchell A. This study group from Cleveland reported that the underlying pathophysiology of PBS/IC is poorly understood and, unfortunately for millions of patients suffering from this debilitating d...

Understanding of the role of urothelium in regulating bladder function is continuing to evolve. While the urothelium is thought to function primarily as a barrier for preventing injurious substances and microorganisms from gaining access to bladder stroma and upper urinary tract, studies indicate it may also function in cell signaling events relating to voiding function. This review highlights ...

Received May 2006 Accepted February 2007 INTRODUCTION Inflammatory pseudotumor of the bladder is a rare benign proliferative lesion that resembles a neoplastic tumor.(1-5) Most of the tumors of the bladder are malignant, and transitional cell carcinoma is the most common malignant tumor; however, other tumors such as adenocarcinoma, squamous cell carcinoma, sarcoma, and teratoma have to be incl...

PURPOSE No standard case definition exists for interstitial cystitis/painful bladder syndrome for patient screening or epidemiological studies. As part of the RAND Interstitial Cystitis Epidemiology study, we developed a case definition for interstitial cystitis/painful bladder syndrome with known sensitivity and specificity. We compared this definition with others used in interstitial cystitis...

OBJECTIVE We evaluated the prevalence of positive potassium sensitivity and cystoscopy with hydrodistention findings in patients with overactive bladder. METHOD This was a prospective cohort study of 98 patients who presented with overactive bladder symptoms. The diagnosis of overactive bladder is established by the presence of irritable voiding symptoms. All patients completed a PUF question...

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help unde...

www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. It has been over 30 years since the Interstitial Cystitis Association of America (ICA) was established in 1984. Although a great deal more is understood about interstitial cystitis/bladder pain syndrome (IC/BPS), the cause and cure of this condition remains unknown. One hypothesis regarding etiology that appears to ha...

Myofascial trigger points (MTPs) have been described as focal areas of tenderness within a muscle belly and have been identified as sources of pain. Soft-tissue manual therapy (MTP release) can be used to manage trigger point pain. Interstitial cystitis and painful bladder syndrome (IC/PBS) are characterized by symptoms of pelvic pain, frequency, urgency and nocturia, but the definitions and di...