a new series of transition metal complexes of co(ii), ni(ii), cu(ii) and zn(ii), has beensynthesized from the knoevenagel condensate schiff base ligand(l) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. structural features were determinedby spectral and analytical techniques. square-planar geometry has been adopted by thecomplexes except cobalt complex which ...

AChE is an enzyme that is predominate in a healthy brain, while BChE is considered to play a minor role in regulating the levels of ACh (memory molecule) in the brain. In addition to setting the ACh level, these two enzymes also facilitate Aβ aggregation by forming stable complexes and participate in the abnormal phosphorylation of the tau protein, which also contribute to the development of Al...

Bleomycin (BLM) biosynthesis has been studied as a model for hybrid peptide-polyketide natural product biosynthesis. Cloning, sequencing, and biochemical characterization of the blm biosynthetic gene cluster from Streptomyces verticillus ATCC15003 revealed that (1) the BLM hybrid peptide-polyketide aglycon is assembled by the BLM megasynthetase that consists of both nonribosomal peptide synthet...

common variable immunodeficiency (cvid) is the most common symptomatic primary antibody deficiency, characterized by reduced serum immunoglobulins levels and increased susceptibility to recurrent pyogenic infections. in this study, we evaluated cd40 ligand expression on stimulated versus unstimulated t-helper lymphocytes of nine common variable immunodeficient patients in comparison with fiftee...

in this study a new simple selective and sensitive spectrophotometric procedure for determination of fe(iii) is described. it is based on the formation of a colored complex between ferric iron and ethyl maltol, a strong and highly selective ligand for fe(iii). after mixing sample and reagent, and incubating at the room temperature, fe(iii)-ethyl maltol complex was extracted with different solve...

A new unsymmetric thioether diamine N - ( 2 - ( 2 - aminophenylthio) ethyl) benzene - 1 , 2 - diamine was prepared through the nucleophilic substitution of cysteaminium chloride with 1 - chloro - 2 - nitrobenzene and then the nitro groups of prepared compuond converted to the amine by zinc powder and ammonium chloride. Then, unsymmetric Schiff bass ligand 2 - ((( 2 - (( 2 - (( 2 - (( 2 - hydrox...

This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

A series of electronegative π-conjugated compounds composed of carbonyl-bridged bithiazole and alkyl-substituted dioxocyclopenta[b]thiophene were synthesized as a candidate for solution-processable n-type organic semiconductor materials and characterized on the basis of photophysical and electrochemical properties. Cyclic voltammetry measurements showed that the first half-wave reduction potent...

The biosynthetic gene clusters for the glycopeptide antitumor antibiotics bleomycin (BLM), tallysomycin (TLM), and zorbamycin (ZBM) have been recently cloned and characterized from Streptomyces verticillus ATCC15003, Streptoalloteichus hindustanus E465-94 ATCC31158, and Streptomyces flavoviridis ATCC21892, respectively. The striking similarities and differences among the biosynthetic gene clust...