Phenytoin (Diphenyl Hydantoin or Dilantin) is highly effective and widely prescribed anticonvulsant agent used in the treatment of grand mal and psychomotor epilepsy. Phenytoin has been used to treat thought, mood and Behavior disorders, cardiovascular disorders, Neuro muscular disorders, gastrointestinal disorders, Endocrine disorders.

A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.

In the title compound, C15H18N2O2S, the 2,3-di-hydro-1-benzo-thio-pyran ring adopts a sofa conformation and the hydantoin ring is twisted with respect to the benzene ring at 78.73 (17)°. In the crystal, pairs of N-H⋯O hydrogen bonds link the mol-ecules into inversion dimers.

We report a patient with fetal hydantoin syndrome and hypoplastic left heart. Only three other cases with this association have been described. This case also highlights the importance genetic variation plays in the phenotypic variability of teratogens and the importance of good prenatal care to minimize risk of teratogenesis.

Despite some remarkable achievements, there are several challenges facing Brazil's Family Health Strategy (FHS), including expanding access to primary care and improving its quality. These concerns motivated the development of the National Program for Improving Primary Care Access and Quality (PMAQ). Although voluntary, the program now includes nearly 39 000 FHS teams in the country and has led...

Dianionic enolates formed from N'-aryl urea derivatives of amino acids undergo intramolecular C-arylation by attack of the enolate anion on the N'-aryl ring, leading to a hydantoin derivative of a quaternary amino acid. In situ IR studies allow identification of four intermediates on the reaction pathway.

A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting L-(+)-tartaric acid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ-unsaturated ketoacids and urea under environmentally benign and simple reaction conditions.

The title compound, C(21)H(19)ClN(2)O(5), is a tetra-substituted hydantoin derivative which contains an imidazolidine-2,4-dione core. The dihedral angle between the aromatic rings is 64.53 (14)°. In the crystal, weak inter-molecular C-H⋯O hydrogen bonding is found. An intra-molecular C-H⋯O inter-action also occurs.

An efficient iridium-catalyzed asymmetric hydrogenation of the fluorinated isoquinoline derivatives has been successfully developed for the synthesis of chiral fluorinated tetrahydroisoquinoline derivatives with up to 93% ee. This methodology features the use of a hydrochloride salt as well as a catalytic amount of halogenated hydantoin which were vital for the reactivity, enantioselectivity, a...