نتایج جستجو برای: bis coumarin

تعداد نتایج: 51675  

2017
Binoy Varghese Cheriyan Parimala Kadhirvelu Jagan Nadipelly Jaikumar Shanmugasundaram Vijaykumar Sayeli Viswanathan Subramanian

AIM To evaluate the anti-nociceptive activity of 7-methoxy coumarin isolated from ethyl acetate fraction of the alcoholic extract of Eupatorium triplinerve Vahl. MATERIALS AND METHODS The shade dried leaves of E. triplinerve were extracted with ethyl alcohol and the extract was condensed. This extract was fractionated with n-hexane, ethyl acetate, and n-butanol. The ethyl acetate fraction was...

Journal: :Journal of cell science 1988
J V Small S Zobeley G Rinnerthaler H Faulstich

7-Diethylamino-3-(4-isothiocyanotophenyl)-4-methylcoumarin (CPITC) was coupled to amino-methyldithiolanophalloidin to produce a new phalloidin derivative, coumarin-phalloidin, fluorescent in the blue region of the spectrum. Coumarin-phalloidin binds to actin with around 100-fold less affinity than unconjugated phalloidin, but with enough avidity to make it a useful stain for actin filaments. Ap...

Journal: :The Journal of biological chemistry 2005
Donghak Kim Zhong-Liu Wu F Peter Guengerich

Cytochrome P450 (P450) 2A6 is an important human enzyme involved in the metabolism of many xenobiotic chemicals including coumarin, indole, nicotine, and carcinogenic nitrosamines. A combination of random mutagenesis and high-throughput screening was used in the analysis of P450 2A6, utilizing a fluorescent coumarin 7-hydroxylation assay. The steady-state kinetic parameters (k(cat) and Km) for ...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
X Zhuo J Gu Q Y Zhang D C Spink L S Kaminsky X Ding

Coumarin was previously found to cause tissue-selective toxicity in the olfactory mucosa (OM) of rats and mice, with rats being the more sensitive species. The aim of this study was to explore the role of target tissue biotransformation in OM-selective toxicity and the metabolic basis of the species differences in coumarin toxicity. At least six coumarin metabolites were detected in OM microsom...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2011
Verònica Ventura Josep Solà Carles Celma Concepción Peraire Rosendo Obach

Irosustat is a novel steroid sulfatase inhibitor for hormone-dependent cancer therapy. Its structure is a tricyclic coumarin-based sulfamate that undergoes desulfamoylation in aqueous solution, yielding the sulfamoyl-free derivative, 667-coumarin. The aim of the present work was to study the in vitro metabolism of irosustat, including its metabolic profile in liver microsomes and hepatocytes, t...

Ladan Edjlali, Moosa Es' haghi, zhila zareakbari,

Alzheimer's disease is an irreversible and progressive brain disorder that slowly destroys memory and thinking skills and ultimately the ability to do the simplest things and can lead to death. Cholinesterases (ChEs) play an important role in controlling cholinergic transmission, and subsequently, by inhibiting CHEs, acetylcholine levels in the brain are elevated. Coumarins have been shown to e...

Journal: :ACS omega 2021

A new sustainable green protocol for obtaining polyethylene glycol (PEG) conjugates, with a prototype molecule, which in this work was coumarin, by means of click chemistry is presented. The organic solvents commonly used type reaction were replaced supercritical carbon dioxide (scCO2). synthesis and characterization PEG-coumarin successfully reported using FTIR, 1H NMR, MALDI TOF. Subsequently...

Journal: :Journal of Supercritical Fluids 2022

Lipids and coumarin were extracted from cumaru seeds using Soxhlet extraction (SE) with ethanol (EtOH) ethyl acetate (EtOAc), scCO 2 , +EtOH +EtOAc, either in a single or sequential stages, PLE EtOH. ScCO +EtOAc provided yields 28% to 31%, independently of the conditions employed, provide top yield 38%, at 25 MPa 80 ºC. Extraction enhanced by three extractions, resulting 44.0% 56.5% for +EtOH, ...

2009

Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon, are commonly prescribed as oral anticoagulants for the treatment of thromboembolic disorders. Therapy with coumarin derivatives is most effective when the international normalized ratio (INR) is kept within a narrow range. Prescribing of these drugs is difficult because of their narrow therapeutic window and the wide inter...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2004
Jeffrey D Vassallo Sarah M Hicks Stephanie L Born George P Daston

Coumarin-induced mouse Clara cell toxicity is thought to result from the local formation of coumarin 3,4-epoxide (CE). However, this toxicity is not observed in the rat, indicating species differences in coumarin metabolism. The purpose of the present work was to characterize the in vitro kinetics of coumarin metabolism in mouse, rat, and human whole lung microsomes, and to determine whether sp...

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