CZostridium propionicum evidently possesses a mechanism for the conversion of lactate to propionate different from that found in the previously studied propionic acid producing bacteria. Reactions common to certain propionibacteria and VeiZZoneZZa gazogenes which could not be demonstrated with Cl. propionicum include : ( a ) the decarboxylation of succinic acid ; (b) the fermentation of malate ...

Abstract The self-assembly of three different generations hyperbranched polyester-polyol polymers, based on 2,2-bis(methylol)propionic acid units (H20, H30, and H40 Boltorn®), carbon electrodes was studied. physico-chemical properties this family polymers confined a surface were explored by electrochemical impedance spectroscopy (EIS) atomic force microscopy (AFM). Surface pKa the polymer layer...

Understanding the complex mechanisms underlying redox-mediated biological processes is a fundamental pillar of cellular biology. We describe identification and quantification disulfide formation reduction in response to phosphine–borane complexes. illustrate specific cysteine effects novel bis(3-propionic acid methyl ester) phenylphosphine–borane (PB1) on cultured 661W cells. A total 1073 uniqu...

The major pathway of histidine metabolism in animals and bacteria other than incorporation into protein involves first deamination to urocanic acid, then the anaerobic addition of water to form an intermediate generally considered to be 4(5)imidazolone-5(4)-propionic acid (1, 2). Finally, the ring is split enzymatically to ~formiminoglutamic acid (3) which is converted to free cglutamic acid by...

α-amino acids bearing aromatic side chains are important synthetic units in the synthesis of peptides and natural products. Although various β-C-H arylation methodologies for amino acid derivatives involving the assistance of directing groups have been extensively developed, syntheses that directly employ N-protected amino acids as starting materials remain rare. Herein, we report an N-acetylgl...

We investigated whether 3-(trihydroxygermyl) propionic acid increases the formation of cornified cell envelopes and the level of ceramide in cultured epidermal keratinocytes and in a three-dimensional human epidermis model. The activity and mRNA expression of transglutaminase were increased when 3-(trihydroxygermyl) propionic acid was added to the cell cultures. The formation of cornified cell ...

In the isolated inner ear of the axolotl (Ambystoma tigrinum) acid pH decreased and basic pH increased the resting and mechanically evoked spike discharge of semicircular canal afferent neurons. Variations in pH also modified the afferent neuron response to N-methyl-D-aspartic acid (NMDA) acid and to (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). Responses to both excita...

We investigated the effect of the excitatory amino acid (EAA) receptor agonists L-glutamate, N-methyl-D-aspartate (NMDA), (RS)-a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainic acid on KCl-induced contractions of rabbit tracheal smooth muscle, as well as the role of epithelium and endogenously produced nitric oxide and prostaglandins on these responses. L-Glutamate decreas...

All ionotropic glutamate receptor (iGluR) subunits analyzed so far are heavily N-glycosylated at multiple sites on their amino-terminal extracellular domains. Although the exact functional significance of this glycosylation remains to be determined, it has been suggested that N-glycosylation may be a precondition for the formation of functional ion channels. In particular, it has been argued th...