نتایج جستجو برای: bioreduction
تعداد نتایج: 372 فیلتر نتایج به سال:
BACKGROUND Biocatalytic asymmetric reductions with whole cells can offer high enantioselectivity, environmentally benign processes and energy-effective operations and thus are of great interest. The application of whole cell-mediated bioreduction is often restricted if substrate and product have low water solubility and/or high toxicity to the biocatalyst. Many studies have shown that a biphasi...
We applied Horse Liver Alcohol Dehydrogenase (HLADH) to the enantioselective synthesis of six (2S)-2-arylpropanols, useful intermediates in the synthesis of Profens. The influence of substrate structure and reaction conditions on yields and enantioselectivity were investigated. The high yields and high enantioselectivity towards the (S)-enantiomer obtained in the bioreduction of 2-arylpropionic...
1,2,4-Benzotriazine 1,4-di-N-oxides are potent antitumor drug candidates that undergo in vivo bioreduction leading to selective DNA damage in the low oxygen (hypoxic) cells found in tumors. Tirapazamine (TPZ) is the lead compound in this family. Here we report on the synthesis, crystal structure, and conformational analysis of a new analog, 3-cyclopropyl-1,2,4-benzotriazine 1,4-di-N-oxide (3). ...
The asymmetric bioreduction of a library of β-cyanoacrylate esters using ene-reductases was studied with the aim to provide a biocatalytic route to precursors for GABA analogues, such as pregabalin. The stereochemical outcome could be controlled by substrate-engineering through size-variation of the ester moiety and by employing stereochemically pure (E)- or (Z)-isomers, which allowed to access...
The main objective of this study was to achieve the continuous biorecovery and bioreduction Pb(II) using an industrially obtained consortia as a biocatalyst. An upflow anaerobic sludge blanket reactor used in treatment process. bioremediation technique that applied made use yeast extract microbial substrate Pb(NO3)2 source Pb(II). UASB exhibited removal efficiencies between 90 100% for inlet Pb...
INVESTIGATION OF ENANTIOSELECTIVE BIOREDUCTION CONDITIONS OF ACETOPHENONE TO (S)-(-)-1-PHENYLETHANOL
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