Sistem limfatik saat ini telah banyak digunakan sebagai jalur penghantaran obat terutama pada terapi antikanker, antivirus, dan imunologi. Jalur juga terbukti memiliki keunggulan yang dapat memberikan efek lebih baik. Akan tetapi, sediaan farmasi untuk obat-obatan bertarget di kini termasuk Biopharmaceutics Classification System (BCS) kategori II, yaitu dengan kelarutan rendah permeabilitas Hal...

This workshop report summarizes the proceedings of Day 2 a three-day on “Current State and Future Expectations Translational Modeling Strategies to Support Drug Product Development, Manufacturing Changes Controls”. From drug product quality perspective, physiologically based biopharmaceutics modeling (PBBM) is tool link variations in attributes vivo outcomes enabling establishment clinically re...

INTRODUCTION Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. METHODS Solid dispersion of prednisolone was prepared with PEG 6000 or different carbohydrates such as lactose a...

This article provides an overview of the patient-specific and drug-specific variables that can affect drug absorption following oral product administration. The oral absorption of any chemical entity reflects a complex spectrum of events. Factors influencing product bioavailability include drug solubility, permeability, and the rate of in vivo dissolution. In this regard, the Biopharmaceutics C...

Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing stavudine (d4T) are reviewed. According to Biopharmaceutics Classification System (BCS), d4T can be assigned to BCS class I. No problems with BE of IR d4T formulations containing different excipients and produced by diffe...