Stroke-prone SHR (SHRSP) are regarded as being proper animal models for stroke in man (Yamori et al: Clin Exp Pharmacol Physiol (Suppl) 3: 199, 1976, Handa et al: In "Spontaneous Hypertension" 294, DHEW Publication No. (NIH) 77-1179, 1977). Studies on the pathogenesis of stroke confirmed the pathogenic importance of arterionecrosis in stroke in SHRSP; cerebral bleeding is caused by the rupture ...

Polymer electrode membrane (PEM) fuel cell has been intensively investigated to improve its output power as a new alternative energy resource. One vital part of PEM fuel cell is its membrane and its critical role in power production of fuel cell. Specifically, the thermal, hydrodynamic and ionic properties of membrane form the core mechanisms of energy generation inside PEM fuel cell. In this s...

The genome of Arabidopsis thaliana contains seven Hsp90 family genes. Three organellar and two cytosolic AtHsp90 isoforms were characterized by functionally expressing them in a temperature-sensitive Hsp90 mutant and a conditional Hsp90-null mutant of Saccharomyces cerevisiae. The cytosolic AtHsp90-1 and AtHsp90-2 showed function similar to that of yeast in chaperoning roles; they could support...

Tetrazine (Tz) is expected to be used for bioimaging and as an analytical reagent. It is known to react very fast with trans-cyclooctene under water in organic chemistry. Here, to understand the interaction between Tz and biomembrane constituents, we first investigated the interfacial behavior of a newly synthesized Tz derivative comprising a C18-saturated hydrocarbon chain (rTz-C18) using a La...

The aim of the present work was to investigate the effects of different surfactants at various concentrations as a skin penetration enhancer through the biomembrane of the shed skin of Naja kaouthia. Additionally, the enhancer mechanism(s) of each class of surfactants were evaluated using physical characterization techniques, such as scanning electron microscopy (SEM), attenuated total reflecta...

Different types of lipid bilayers/monolayers have been used to simulate the cellular membranes in the investigation of the interactions between drugs and cells. However, to our knowledge, very few studies focused on the influence of the chosen membrane model upon the obtained results. The main objective of this work is to understand how do the nature and immobilization state of the biomembrane ...

The components and ratio of lipids species assembled into biomembrane is another essential factor contributing to the specific behaviors of lipid rafts. From two lipid metabolism genes mutation models, we understood that the nature of biomembrane are very different between mammals and Drosophila. NeutralCeramidase (N-CDase) nude mice do not have significant phenotype, even the N-CDase nude MEFs...