The long path from initial research on oligonucleotide therapies to approval of antisense products is not unfamiliar. This lag resembles those encountered with monoclonal antibodies, gene therapies, and many biological targets and is consistent with studies of innovation showing that technology maturation is a critical determinant of product success. We previously described an analytical model ...

Microbial cellulose has proven to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavors, such as paper products, electronics, acoustics, and biomedical devices. In fact, biomedical devices recently have gained a significant amount of attention because of an increased interest in tissue-engineered products for both wound care and the regeneration o...

Extracting biomedical relations such as drug-drug interaction (DDI) from text is an important task in biomedical NLP. Due to the large number of complex sentences in biomedical literature, researchers have employed some sentence simplification techniques to improve the performance of the relation extraction methods. However, due to difficulty of the task, there is no noteworthy improvement in t...

Lanthionine-containing peptides (lanthipeptides) are a rapidly growing family of polycyclic peptide natural products belonging to the large class of ribosomally synthesized and post-translationally modified peptides (RiPPs). These compounds are widely distributed in taxonomically distant species, and their biosynthetic systems and biological activities are diverse. A unique example of lanthipep...

Rare diseases are an important public health issue with high unmet need. The introduction of the EU Regulation on orphan medicinal products (OMP) has been successful in stimulating investment in the research and development of OMPs. Despite this advancement, patients do not have universal access to these new medicines. There are many factors that affect OMP uptake, but one of the most important...

Biotechnology has become one of the primary technology development areas of the 21 century. For a medical device or pharmaceutical manufacturer to remain on the competitive edge, not only is it necessary to satisfy the stringent demands of the biotechnology markets, but those companies must also develop processes that can accelerate the time frame from research and development to manufacturing ...

Natural products have proven to be valuable sources for the identification of new drug candidates, and also as tools for chemical biology and medicinal chemistry research [1]. In fact, if we trace back human history, many natural products have also long been used to treat various human disorders and distinguished by their drug-like properties [2]. To date, tens of thousands of bioactive compoun...

Pharmacology is an integrative discipline that originated from activities, now nearly 7000 years old, to identify therapeutics from natural product sources. Research in the 19th Century that focused on the Law of Mass Action (LMA) demonstrated that compound effects were dose-/concentration-dependent eventually leading to the receptor concept, now a century old, that remains the key to understan...

objective(s): this paper describes coating of magnetite nanoparticles (mnps) with amorphous silica shells.   materials and methods: first, magnetite (fe3o4) nps were synthesized by co-precipitation method and then treated with stabilizer molecule of trisodium citrate to enhance their dispersibility. afterwards, coating with silica was carried out via a sol-gel approach in which the electrostati...