OBJECTIVES We investigated whether a multiple biomarkers strategy that includes plasma levels of endothelium-derived microparticles (EMP), reflecting endothelial dysfunction, can improve prediction of future cardiovascular events in patients at high risk for coronary heart disease (CHD). BACKGROUND Detailed risk stratification using multiple biomarkers can provide clinical benefits in high-ri...

Is There a Need for New Cardiovascular Biomarkers? Discovery of novel biomarkers and improvement of risk prediction algorithms will be a key to fulfill the promise of personalized medicine. Although genuine personalized treatment is probably an unrealistic expectation within the budget constraints of current health systems, a stratified medicine approach to identify individuals at high risk may...

Obesity and overweight are among the major health problems in the world today. The excessive accumulation of fat in adipose tissue is accompanied by low‐grade inflamma‐ tion, adipokine secretion dysregulation, oxidative stress, and an alteration of the secretion of gut hormones and food intake related to peptides. This is related to the development of cardiovascular diseases, which have been in...

The central role of oxidative signalling in cardiovascular pathophysiology positions biometric measures of redox state as excellent markers for research and clinical application. However, despite this tantalizing biological plausibility, no redox biomarker is currently in widespread clinical use. Major recent insights into the mechanistic complexities of redox signalling may yet provide the opp...

According to the Merriam-Webster Online Dictionary, a biomarker is ‘a distinctive biological or biologically derived indicator (as a metabolite) of a process, event, or condition (as aging, disease, or oil formation)’ [1]. A biomarker can be structural, such as mammography or a coronary calcium scan, or functional, such as glomerular filtration rate or blood pressure, but the term biomarker is ...

BACKGROUND Cardiovascular disease is one of the major causes of death worldwide. Assessing the risk for cardiovascular disease is an important aspect in clinical decision making and setting a therapeutic strategy, and the use of serological biomarkers may improve this. Despite an overwhelming number of studies and meta-analyses on biomarkers and cardiovascular disease, there are no comprehensiv...

The use of biomarkers has proven utility in cardiovascular medicine and holds great promise for future advances, but their application requires considerable rigor in thinking and methodology. Numerous confounding factors can cloud the clinical and investigative uses of biomarkers. Yet, the thoughtful and critical use of biomarkers can doubtless aid discovery of new pathogenic pathways, identify...