Neoplastic cells typically possess numerous genomic mutations and chromosomal aberrations, including point mutations, gene amplifications and deletions, and replication errors. Acquisition of such genomic instability may represent an early step in the process of carcinogenesis. Proteins involved in DNA replication, DNA repair, cell cycle progression, and others are all components of complex ove...

Nutmeg, the dried seed kernel of Myristica fragrans, MF (Family: Myristicaceae) possesses antifungal, hepatoprotective and antioxidant properties. Its radioprotective effect against 6, 8 and 10 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded LD(50/30 )as 6.83 Gy and 8.89 Gy for irradiated only and (MF + radiation) groups, respectively. The dose reduction f...

Although, the dexamethasone have been used for the managements, against various ailments as single API or in combination with other drugs as acetate or palmitate salt. However, Dexamethasone as palmitate salt has not been investigated so far for sub acute toxicity on intravenous administration. Therefore, an attempt has been made to investigate sub-acute toxicity of dexamethasone palmitate inje...

Background: The battery recycling and manufacturing involves the use of metallic lead for making grids, bearing and solder. The process results in release of lead particles and lead oxide causing environmental pollution and severe lead poisoning. Aims and Objectives: To know the present scenario of the blood lead level and its biochemical effects on occupational lead-exposed population, mainly ...

BACKGROUND N- and O-oligosaccharide variants on glycoproteins (glycoforms) can lead to alterations in protein activity or function that may manifest themselves as overt disease. APPROACH This review summarizes those diseases that are known to be the result of an inherited or acquired glycoprotein oligosaccharide structural alteration and that are diagnosed in blood or urine by chemical charac...

BACKGROUND The omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA) have well-characterized effects on inflammation and oxidative stress and may have neuroprotective effects in a number of neurodegenerative conditions including AD. Brain tissue contains large amounts of polyunsaturated fatty acids, which are particularly vulnerable to free radical injury. PURPOSE The present...

Neuritic (senile) plaques are a hallmark of the pathology found in the brain of patients afflicted with Alzheimer's disease (AD). Neuritic plaques have been considered to be composed of an amyloid core surrounded by dilated neurites, although the use of anti-beta/A4-protein antibody revealed the presence of diffuse plaques without a nuclear-like central mass or surrounding paired helical filame...

In today’s environment of shrinking resources, and consistent need for accurate inspections, simulation software is an effective cost cutting tool. CIVA is an advanced NDT simulation software dedicated to modeling ultrasonic (UT), radiographic (RT) and eddy current (ET) inspections without the need for physical test sample or inspection equipment. Each inspection module is comprised of simulati...

Since the beginning of the nineties, the CEA (the French Atomic Energy Commisssion), with developing the CIVA NDT expertise platform is greatly involved in the development of simulation tools. Over the years, and with successive versions of CIVA, the results of modeling research work have been being integrated into the software both for ultrasonics and Eddy current techniques. In order to fullf...

Collaboration networks provide a method for examining the highly heterogeneous structure of collaborative communities. However, we still have limited theoretical understanding of how individual heterogeneity relates to network heterogeneity. The model presented here provides a framework linking an individual’s skill set to her position in the collaboration network, and the distribution of skill...