Novel, non-steroidal anti-inflammatory drug (NSAID), acetaminophen conjugates 6a–l with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates (6d, 6e, 6h, and 6k) exhibit more potent anti-inflammatory activity than their parent drugs, (b) the potent bis-conjugates show no visible stomach le...

One of the key requirements in semi-crystalline polyesters, synthetic or bio-based, is the control on crystallization rate and crystallinity. One of the limiting factors in the commercialization of the bio-based polyesters, for example polyhydroxyalkanoates synthesized by bacteria for energy storage purposes, is the slow crystallization rate. In this study, we show that by tailoring the molecul...

The rapid increase in agricultural waste is rising across the globe and a big environmental challenge. utilization of ginger as valuable product very limited. up-cycling an effective approach for valorization. Ginger contains many bio-active compounds. These bioactive compounds possess various functional properties. literature has indicated that its rich source shogaol zingerone gingerols, thes...

Despite the abundance of palm-based residues generated, by-products from thermochemical processing such as bio-oil may create value-added products to palm industry. The derived contains high aromatic compounds, which are active ingredients in bio-pesticides formulation. Therefore, this study investigated formulation bio-pesticide and determines their effect on insect-pest oil Metisa plana walke...

Fungal pathogens continue to pose challenges to humans and plants despite efforts to control them. Two coumarins, robustic acid and thonningine-C isolated from Millettia thonningii, show promising activity against the fungus Candida albicans with minimum fungicidal concentration of 1.0 and 0.5 mg/mL, respectively. Molecular modelling against the putative bio-molecular target, lanosterol 14α-dem...

Background Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides are the main alkamides in Echinacea preparations, which have been demonstrated to possess biological activities in various bio-assays, such as immune-modulating activities and effects on cannabinoid receptors [1]. Therefore, the evaluation of systemic availability of these active plant constituents is a major prerequisite for the i...