Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...

background: beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in so...

Background: Are dietary patterns, substantiated by biomarkers, associated with semen quality? Materials and Methods: In 161 men of subfertile couples undergoing in vitro fertilization treatment in a tertiary referral clinic in Rotterdam, the Netherlands, we assessed nutrient intakes and performed principal component factor analysis to identify dietary patterns. Total homocysteine (tHcy), folate...

Cancer cell drug resistance develops via several mechanisms, including apoptosis evading, efflux, reprogramming, DNA repair. Recently numerous data pointed out an ability of cancer cells reversibly exit from cycle to enter in G0 phase that may favor survival. Therefore, the goal study was determine transcriptional phenotype associated with quiescent/senescent state acquisition. Melanoma were tr...