Previous reports suggest that regular use of beta-agonists does not lead to tolerance to their bronchodilator effects. However, most studies have been conducted in stable asthma. This study investigates whether bronchodilator tolerance can be demonstrated during acute bronchoconstriction. Thirty-four asthmatic subjects were treated with 6 weeks inhaled terbutaline (1 mg q.i.d.), budesonide (400...

BACKGROUND Long-acting beta-agonists may increase the risk for fatal and nonfatal asthma exacerbations. PURPOSE To assess the risk for severe, life-threatening, or fatal asthma exacerbations associated with long-acting beta-agonists. DATA SOURCES English- and non-English-language searches of MEDLINE, EMBASE, and Cochrane databases; the U.S. Food and Drug Administration Web site; and referen...

AIM The aim of this study was to investigate the co-prescribing of beta-antagonists and beta-agonists in the community, and to assess the potential hazards of such co-prescribing. METHODS The study was set in the population of Tayside, Scotland (population approximately 400,000), between January 1993 and March 1993. An automated person-specific prescribing database was used, which could also ...

Tracheal relaxing effects and beta 2-selectivity of TA-2005 were investigated by functional experiments and radioligand binding assay in guinea pigs in comparison with those of other beta-agonists, isoproterenol, procaterol, formoterol and salbutamol. The relaxing activity of TA-2005 on histamine-induced contraction in the isolated trachea was most potent among the five agonists, and it was blo...

drug when nearing exhaustion which would lead to a decline in the response to the drug. Most likely the development of drug tolerance to beta, agonists involves more than one mechanism. The workshop was fruitful in amunulating further evidence that drug tolerance to beta, agonists does develop. It is clear that further studies are needed to define the clinical sigdicance of drug tolerance, the ...

AMA: Acute Medical Department; ATC: Anatomical Therapeutic Chemical; COPD: Chronic Obstructive Pulmonary Disease; CPR: Central Person Register; CRP: C-Reactive Protein; DDD: Defined Daily Doses; EPJ: Electronic Patients Journal; FDC: Fixed Dose Combination; FPAS: Funen Patients Administrative System; GINA: Global Initiative for Asthma; ICD10: International Classification of Disease – 10th editi...