Semicarbazide-sensitive amine oxidase (SSAO) is very abundant at the plasma membrane in adipocytes. The combination of SSAO substrates and low concentrations of vanadate markedly stimulates glucose transport and GLUT4 glucose transporter recruitment to the cell surface in rat adipocytes by a mechanism that requires SSAO activity and hydrogen peroxide formation. Substrates of SSAO such as benzyl...

The photophysical behaviour of N,N-diethyl-2-( 1 -naphthyl)ethylamine I, N-benzyl-N-ethyl-2-(1naphthy1)ethylamine VI and N-ethyl-2(1 -naphthyl) -N(2,4,6-trichlorobenzyI)ethylamine VII, molecules that are able to form intramolecular exciplexes, has been examined in ethyl acetate. Compounds I and VI are fluorescent, but VII is non fluorescent and decomposes with formation of hydrogen chloride. Th...

A benzylamine supported palladium (II) complex has been synthesized and characterized using different spectroscopic techniques, such as FTIR, UV/Vis., 1H, 13C NMR and LCMS. The semi crystalline nature of the complex was investigated through powder XRD and SAED pattern analysed by HRTEM. The in vitro biological study against breast cancer cell lines MCF-7 and MDA-MB-231 was not much effective bu...

AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate (B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids (FFA) and glucose circulating levels. METHODS Adipose tissue (AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of...

A novel copper-depleted bovine serum amine oxidase (BSAO), in which about half the molecules contained the organic cofactor in the oxidized form, was prepared by adding a reductant in anaerobic conditions to the cyanide-reacted protein. The CuI-semiquinone formed in these conditions reoxidizes after the removal of copper. The inactive derivative was reduced by benzylamine at approx. 1/1000 the ...

New N-(benzyl carbamothioyl)-2-hydroxy substituted benzamides 13, 20, and 21 were synthesized using sodium bicarbonate and benzyl amine with 2-thioxo-substituted-1,3-benzoxazines 6, 10a, b, 11c, and 12a-n. The 2-thioxo-substituted-1,3-oxazines 6, 10a-b, 11d 12a-n, and 26 were converted to the corresponding 2-methylthio-substituted-1,3-oxazines 14a-l and 24 which were then converted to 2-benzyl ...

Michael addition reactions of morpholine and benzylamine to methyl 2,3-dideoxy-4,6-0-(phenylmethylene)-3-Cphenylsulfonyl-a-D-erythro-hex-2-enopyranoside 9 furnish glucoderivatives 10 and 11. Desulfonation at C-3 followed by synthetic manipulation produces intermediates for generating various new modified monosaccharides carry ing N-alkyl and N,N-dialkyl amino groups at the C-2 position of hexop...

A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotr...

The data presented in this article are related to the research entitled of UV-A stable nanotubes. The nanotubes have been prepared from 3,5-bis(trifluoromethyl)benzylamine derivative of tyrosine (BTTP). XRD data reveals the size of the nanotubes. As-synthesized nanotubes (BTTPNTs) are characterized by UV-vis optical absorption studies [1] and photo physical degradation kinetics. The resulted da...

A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to form benzyl-o-nitrophenyl carbamate; in the second step the carbamate is reacted with a variety of di...