introduction: chronic liver disease and cirrhosis are the most important causes of growth failure, morbidity and mortality in children. cirrhosis consists of a variety of congenital, genetic, metabolic, and infectious causes in children. models for predicting of chronic liver disease severity, survival, and transplantation are useful for decision-making as well as medical interventions. the mos...

In the title compound, C(21)H(20)N(4)O(4)S(2, )the piperazine ring adopts a chair conformation. The 1-ethyl-indoline-2,3-dione system links to one N atom of the piperazine ring via a carbodithio-ate group. The indoline-2,3-dione ring and the nitro-benzene ring subtend adihedral angle of 37.27 (7)°. In the crystal structure, weak C-H⋯O and π-π stacking inter-actions [centroid-centroid distances ...

Addition of the ambident SCN group to a fullerendione derivative follows two different pathways in the presence and absence of Lewis acid.

C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

Previously we have proposed and provided evidence for a metabolic scheme leading to 3-carbamoyl-2-phenylpropionaldehyde from the antiepileptic drug felbamate. This aldehyde was found to undergo reversible cyclization to form the more stable cyclic carbamate 4-hydroxy-5-phenyl-tetrahydro-1,3-oxazin-2-one or undergo elimination to form 2-phenylpropenal. The cyclic carbamate bears structural simil...

Human body odor, which contains several volatile organic compounds, possesses various odor qualities. To identify key volatile compounds responsible for the common unpleasant odors derived from human axillae and feet, the odor quality and intensity of 118 human axillae and feet were directly evaluated by sniffing, and odor compounds obtained from the subjects were identified. Furthermore, the s...

Introduction: Dione (1124 km in diameter) is a mid-sized icy moon of Saturn which shows a wide range in tectonic features across its surface revealing an intense geologic history. With the two highly evolved satellites Enceladus und Titan, Dione forms a set of three satellites whose surfaces have been shaped by tectonic activity on a global, not only on regional scale. Tectonic forms on Dione w...

Endometrial cancer (EC) is the most common estrogen-dependent gynecological malignancy in the developed World. To investigate the local formation of estradiol (E2), we first measured the concentrations of the steroid precursor androstenedione (A-dione) and the most potent estrogen, E2, and we evaluated the metabolism of A-dione, estrone-sulfate (E1-S), and estrone (E1) in cancerous and adjacent...

Jun/Fos, a crucial factor in transmitting the tumor-promoting signal from the extracellular environment to the nuclear transcription machinery, has a dimerization interface possessing several coiled structural properties. Jun and Fos can interact with the DNA regulatory region, AP-1 (Activator Protein-1), which is composed of 5'-TGAC/GTCA-3'. Curcumin is a well-known anticancer and anti-inflamm...