Behavioral inhibition reflects a disposition to react warily to novel situations, and has been associated with atopic diseases such as asthma. Retrospective work established the relationship between behavioral inhibition in rhesus monkeys (Macaca mulatta) and airway hyperresponsiveness, but not atopy, and the suggestion was made that behavioral inhibition might index components of asthma that a...

Many common psychiatric conditions, such as attention deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), Parkinson's disease, addiction and pathological gambling are linked by a failure in the mechanisms that control, or inhibit, inappropriate behavior. Models of rat behavioral inhibition permit us to study in detail the anatomical and pharmacological bases of inhibitor...

a University of California, Berkeley, Department of Psychology, 3210 Tolman Hall #1650, Berkeley, CA 94720, United States b University of Miami, Department of Psychology, PO Box 248185, Coral Gables, FL 33124, United States c Yale University, Department of Psychology, United States d Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10th Ave, Miami, FL...

Behavioral inhibition (i.e. avoidance of unfamiliar) has been linked to significant differences in stress physiology and health. Developing an animal model of this common temperament provides a means to experimentally study the development and physiology of this trait as it relates to stress-related health processes. To elaborate such an animal model, we studied individual rat responses to two ...