We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a controlled laboratory environment (circadian rhythm, fluid and dietary intakes, mic...

cutaneous sphincterotomy is the treatment of choice for patients with chronic anal fissure. Both procedures are easily and safely performed in the outpatient department under local anaesthesia, thereby avoiding the costs and disruption of admission to hospital. SHORT REPORTS Current practice of diagnostic lumbar puncture About 30%1 of patients have a headache after lumbar puncture,' and many st...