Novel hydrolysis stable 2-(ω-phosphonooxy-2-oxaalkyl)acrylate monomers 3 with phosphoric acid moieties were synthesized by a three step synthesis via Baylis-Hillman reaction of ethyl acrylate and formaldehyde, and subsequent etherification of the obtained product with diols and phosphorylation using POCl(3). The polymerization enthalpy of 2-(ω-phosphonooxy-2-oxaalkyl)acrylates 3 as measured by ...

In this study we performed the total synthesis of the terpene indole alkaloid (+)-ibophyllidine through a pathway involving asymmetric phosphine catalysis, with our novel l-4-hydroxyproline-derived chiral phosphine mediating the key [3 + 2] annulation. Hydrogenation of the [3 + 2] adduct allowed the rapid formation of the stereochemically dense pyrrolidine ring of (+)-ibophyllidine in excellent...

compounds. They exhibit antianaphylactic, oral hypotensive and antiulcer properties. 2-Benzoxepine moiety is present in many useful neuroleptic (pinoxepin), antidepressant (spiroxepin) and anti-inflammatory agents (isoxepac and oxepinac). The synthesis of 2-benzoxepines having different functionalities is thus necessary. As a part of our program related to the discovery of novel bioactive compo...