نتایج جستجو برای: bax bcl 2 ratio
تعداد نتایج: 2885727 فیلتر نتایج به سال:
زمینه و هدف: مکمل کراتین عمومی ترین مکمل است که جهت کمک ارگوژنیکی و نقش درمانی آن پیشنهاد شده است. هدف ما بررسی اثر مکمل سازی کراتین بر فاکتورهای آپوپتوزی bcl-2، bax و نسبت bcl-2/baxدر فعالیت مقاومتی حاد مردان میانسال بود. روش بررسی: در یک طرح کنترل شده-دارونما، دوسوکور، انتخاب تصادفی و همسان سازی شده، بیست و هفت مرد میانسال (43/5 ± 59/45 سال) بطور تصادفی به سه گروه با مصرف روزانه 20 گرم مونوه...
background: modulation of the immune response is an important strategy by which establishment and growth of hydatid cyst in the internal organs of human is warranted. induction of apoptosis in the lymphocytes might be a considerable component. this study was designed to evaluate apoptotic impact of hydatid fluid (hf) on human lymphocytes. methods: human lymphocytes were treated with hydatid f...
BACKGROUND To explore the time-dependent effects of acupuncture on mRNA levels of the apoptotic factors BCL-2 and BAX in a rat cerebral hemorrhage model, slow injection of autologous blood to the caudate nucleus was used to generate the cerebral hemorrhage model. MATERIAL AND METHODS A sham surgery control group, groups with acupuncture applied 3, 9, 24, and 48 hours after model induction, and ...
Introdution: The research has been indicated that reactive oxygen species induced the apoptosis of cardiomyocytes. However, this mechanism has been unclear. The aim of this study was to investigate the effects of concurrent training on some of the heart apoptosis variables (BAX,BCL-2) following by the injection of different H2O2 dose in Wistar rat males. Methods: 50 male rats were randomly a...
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by cleaving or repressing the translation of target mRNAs. In mammal animals, their function mainly represses the target mRNAs transcripts via imperfectly complementary to the 3'UTR of target mRNAs. Several miRNAs have been recently reported to be involved in modulation of glioma development, especially some u...
Studies in cell lines have indicated that expression of the BCL-2 family of proteins is an important determinant of chemotherapy-induced apoptosis; however, the level of expression of these proteins in childhood acute lymphoblastic leukemia (ALL) has not been extensively reported. Using quantitative Western blotting we have determined the level of expression of BCL-2, BAX, MCL-1, and BCL-X in l...
OBJECTIVE Apoptosis of T lymphocytes in the circulation of patients with squamous cell carcinoma of the head and neck (SCCHN) was shown to target effector CD8+ rather than CD4+ T cells. This study evaluates the contribution of pro- and antiapoptotic components of the mitochondria-dependent pathway to apoptosis of circulating CD8+ T cells in these patients. EXPERIMENTAL DESIGN Blood samples we...
Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...
Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...
Background: Testicular ischemia-reperfusion (I/R) injury is a urological emergency that can lead to male infertility. So far, no suitable treatment has been found for it. Therefore, in the present study, we investigate therapeutic effects of concomitant administration coenzyme Q10 (CoQ10) and titanium dioxide nanoparticles (TiO2-NPs) on testicular I/R damage rats expressions genes involved mito...
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