نتایج جستجو برای: bax

تعداد نتایج: 12020  

Journal: :Folia biologica 2006
I Niedzielska Z Niedzielski D Sypniewski U Mazurek T Wilczok J Dabek

Bax is considered one of major effectors of apoptosis--programmed cell death. Immunohistochemical analysis of in vitro patterns of bax expression was mostly investigated in mammalian cell lines and tissues. The present study is the first in vivo molecular analysis of bax expression in oral cavity pathologies. The study population consisted of 45 patients with hyperplasia, neoplasm in situ malig...

ژورنال: :annals of military and health science research 0
نوریه شریفی کامران غفارزادگان محمدجواد فرهمند مجتبی طلایی خویی

سابقه و هدف: سرطان پستان شایعترین تومور بدخیم و در راس علل مرگ و میر ناشی از سرطان در زنان میباشد. آپوپتوزیس نقشی اساسی در چرخه سلولی سلولهای طبیعی و تومورال ایفا می کند. آپوپتوزیس توسط گروهی از پروتئین ها شامل bax و bcl-2 کنترل می شود. در این مطالعه بروز پروتئین های bax و bcl-2 در 46 بیمار مبتلا به سرطان مجرایی مهاجم پستان و ارتباط با بروز ki-67 و گیرنده های استروژن و پروژسترون می پردازیم.   م...

Journal: :Molecular medicine 2001
M E Gibson B H Han J Choi C M Knudson S J Korsmeyer M Parsadanian D M Holtzman

BACKGROUND Hypoxic-ischemic (H-I) injury to the neonatal brain has been shown to result in rapid cell death with features of acute excitotoxicity/necrosis as well as prominent delayed cell death with features of apoptosis such as marked caspase-3 activation. BAX, a pro-apoptotic molecule, has been shown to be required for apoptotic neuronal cell death during normal development but the contribut...

2012
Pedro Eitz Ferrer Paul Frederick Jacqueline M. Gulbis Grant Dewson Ruth M. Kluck

BACKGROUND One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial outer membrane during apoptosis. While Bax is mostly cytosolic and translocates to mitochondria following an apoptotic stimulus, Bak is constitutively integrated within the outer membrane. Membrane anchorage occurs via a C-terminal transmembrane domain that has been studied in Bax but no...

Journal: :Blood 2003
Giovanni Del Poeta Adriano Venditti Maria Ilaria Del Principe Luca Maurillo Francesco Buccisano Anna Tamburini Maria Christina Cox Annibale Franchi Antonio Bruno Carla Mazzone Paola Panetta Giovanna Suppo Mario Masi Sergio Amadori

The inability to undergo apoptosis is a crucial mechanism of multidrug resistance in acute myeloid leukemia (AML), and the analysis of mitochondrial apoptotic proteins may represent a significant prognostic tool to predict outcome. Bcl-2 and Bax oncoproteins were evaluated in 255 de novo AML patients (pts) by flow cytometry using an anti-bcl-2 monoclonal antibody (MoAb) and an anti-bax MoAb. Th...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Russell S Whelan Klitos Konstantinidis An-Chi Wei Yun Chen Denis E Reyna Saurabh Jha Ying Yang John W Calvert Tullia Lindsten Craig B Thompson Michael T Crow Evripidis Gavathiotis Gerald W Dorn Brian O'Rourke Richard N Kitsis

The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in primary necrosis is early opening of the inner membrane mitochondrial permeability transition pore (mPTP), precipitating mitochondrial dysfunction and cessation of ATP synthesis. Bcl-2 proteins Bax and Bak are the principal activators of MOMP ...

1995
Stanislaw Krajewski Carl Blomqvist Kaarle Franssila Maryla Krajewska Veli-Matti Wasenius Eero Niskanen Stig Nordling John C. Reed

Bax is a homologue of Bcl-2 that promotes apoptosis. Bax protein levels were assessed by immunohistochemical methods in primary tumors de rived from 119 women with metastatic breast cancer. These patients had received combination chemotherapy either with a once a month dosage schedule or in 4 weekly divided doses. The BAX immunostaining results were retrospectively compared with overall surviva...

Journal: :Blood 2008
Feng-Ting Liu Samir G Agrawal John G Gribben Hongtao Ye Ming-Qing Du Adrian C Newland Li Jia

Proapoptotic Bcl-2 family member Bax is a crucial protein in the induction of apoptosis, and its activation is required for this process. Here we report that Bax is a short-lived protein in malignant B cells and Bax protein levels decreased rapidly when protein synthesis was blocked. Malignant B cells were relatively resistant to tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-i...

Journal: :American journal of physiology. Heart and circulatory physiology 2003
Edith Hochhauser Shaye Kivity Daniel Offen Nilanjana Maulik Hajime Otani Yael Barhum Hannah Pannet Vladymir Shneyvays Asher Shainberg Valeri Goldshtaub Anna Tobar Bernardo A Vidne

The role of the proapototic Bax gene in ischemia-reperfusion (I/R) injury was studied in three groups of mice: homozygotic knockout mice lacking the Bax gene (Bax(-/-)), heterozygotic mice (Bax(+/-)), and wild-type mice (Bax(+/+)). Isolated hearts were subjected to ischemia (30 min, 37 degrees C) and then to 120 min of reperfusion. The left ventricular developed force of Bax-deficient vs. Bax(+...

2000
Joan Gil Hiroyuki Yamamoto Juan M. Zapata John C. Reed Manuel Perucho

We have reported previously that codon 169 of the proapoptotic gene BAX is a mutational hot spot in gastrointestinal cancer. Two different mutations were found in this codon, replacing the wild-type threonine by alanine or methionine. To compare the proapoptotic activity of these Bax mutants with wild-type Bax, we established an ecdysone (muristerone A)-inducible system in cultured human embryo...

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