Introduction: Despite considerable efforts to control AIDS pandemic, it is still one of the significant infectious concerns worldwide. The advance in medical research has led to the development of highly active antiretroviral therapy with a considerable effect to suppress the disease. However, an effective vaccine capable of eradication the HIV pandemic is not available yet. Failure to develop ...

Background: After substitution of Pentavalent vaccine with diphtheria, tetanus, pertussis (DTP) in the Iranian National Vaccination program with 3 Pentavalent (three times vaccination with Pentavalent vaccine at months 2, 4, and 6) in 2014 and the lack of published research in the field of immunogenicity of pertussis component of this vaccine, the efficacy of pertussis vaccine was studied 6 mon...

It is about 50 years that FMD affected the ruminants of Isfahan. Last outbreaks of FMD were happened at 2005 even vaccinated animals, so in current work using RT-PCR, sequencing and regression "r" values, the isolated strains in Isfahan were identified. The aim of this study was molecular epidemiology of FMDV in Isfahan province as the central part of Iran in 2006-2009. According to the result ...

Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawba...

Background: Melanoma is a common and malignant cutaneous tumor, which is responsible for a large proportion of skin cancer deaths. Dendritic cell (DC)-based vaccines have achieved positive results in the treatment of melanoma because of their ability to induce cytotoxic response to facilitate tumor elimination. Objective: To improve the efficacy of dendritic ce...

OBJECTIVE Intranasal influenza vaccine has proven clinical efficacy and may be better tolerated by young children and their families than an injectable vaccine. This study determined the potential cost-effectiveness (CE) of an intranasal influenza vaccine among healthy children. METHODS We conducted a CE analysis of data collected between 1996 and 1998 during a prospective 2-year efficacy tri...

Abstract Fowl pox vaccine is produced in the Razi Institute for almost half a century and has a favorable and productive yield in poultry flocks and has provided complete satisfaction to the poultry breeder. In terms of comparing the efficacy of this vaccine with imported vaccines, the following research was conducted. In this study, based on the latest protocols of European Pharmacopeia and O...

the plaque forming unit (pfu) and tissue culture infectious dose50 (tcid 50 ) methods are used for evaluation of vaccine heat stability and effect of various stabilizers on thermal stability of vaccines. the aim of present study is using real-time pcrtechniquefor estimation of vaccine degradation rate and thermal stability of measles vaccines. lyophilized measles vaccines containing three vario...

in early 1990, an outbreak of measles occurred in kerman, (population 257, 284) iran. overall, 475 cases were identified and four died (case fatality ratio 5.4 per thousand). illness was limited primarily to children below 15 years of age 166 (22.3%) were in children under five, 573 (77%) between 5-14 and six (0.8%) above 15 years of age. the age of the cases ranged from five months to 35 years...