Chat (Cas/HEF1-associated signal transducer) is a novel signaling molecule with an N-terminal SH2 domain and C-terminal Cas/HEF1 association domain that is implicated in the regulation of cell adhesion. The Cas/HEF1 association domain also shows sequence similarity with guanine nucleotide exchange factors for Ras family small GTPases. In this study, we found significant activation of Rap1 in Ch...

Background: Myenteric interneurones are involved in the reflexes that control the motility of the human colon. Aims: The distribution of choline acetyltransferase (ChAT) and nitric oxide synthase (NOS) immunoreactivity in myenteric interneurones was investigated in this study. Methods: DiI (1,1′didodecyl 3,3,3′,3′-indocarbocyanine perchlorate) was applied to the myenteric plexus of the human co...

The M-transcript of human choline acetyltransferase (ChAT) produces an 82-kDa protein (82-kDa ChAT) that concentrates in nuclei of cholinergic neurons. We assessed the effects of acute exposure to oligomeric amyloid-β1-42 (Aβ1-42) on 82-kDa ChAT disposition in SH-SY5Y neural cells, finding that acute exposure to Aβ1-42 results in increased association of 82-kDa ChAT with chromatin and formation...

Multi-user applications are commonly implemented using a centralized server. This paper presents a new design for multi-user chat applications (Chronos) that works in a distributed, serverless fashion over Named Data Networking. In Chronos, all participants share their views by exchanging the cryptographic digests of the chat room data set. A newly generated message causes a change of the diges...

We present a new medium-access control protocol for ad hoc networks that does not require carrier sensing or the preassignment of unique codes to nodes to ensure that intended receivers receive unicast, or multicast, or broadcast data packets without interference from hidden sources. We call this new protocol channel hopping access with trains (CHAT). CHAT combines the notion of packet trains w...

Chat rooms, recommendation sites, and customer review sections provide consumers with an opportunity to overcome geographic boundaries and to communicate based on mutual interests. However, marketers have incentives to anonymously supply promotional chat or reviews in order to influence the consumer's evaluation of their products. This, in turn, lowers the credibility of word of mouth transmitt...

Intelligibility in a telecommunication-based conference application can largely be improved, when the speech signals of the different interlocutors are presented spatially, and when the sources are spatially distributed. For the controlled exploitation of the underlying Cocktail Party Effect in speech chat applications, a prediction of the intelligibility related to a given spatial configuratio...

Choline acetyltransferase (ChAT) is the biosynthetic enzyme of acetylcholine. In mammalian tissues, it is encoded by multiple mRNAs with different 5'-ends. This diversity results from the alternative usage of three promoters and from differential splicing events. Here, we show that the first intron of the rat ChAT gene contains an open reading frame that encodes a potential vesicular acetylchol...

Data generated by video applications are rarely mined for context in order to augment and improve user experiences. In this paper, we propose an innovative approach to extract context from video streams dynamically. As a case study we apply this approach in a context based multimedia chat application. In particular, this paper discusses how we perform video stream analysis to recognize faces an...

This study investigated the effects of transformational and transactional leadership styles and communication media on team interaction styles and outcomes. Teams communicated through one of the following three ways: (a) face-to-face, (b) desktop videoconference, or (c) text-based chat. Results indicated that transformational and transactional leadership styles did not affect team interaction s...