A lesion of nevus sebaceus with multifocal basal-cell carcinomas was excised by Mohs' fresh-tissue technique. Histologically, most of the foci of basal-cell carcinomatosis were of the superficial type, but the few more deeply situated foci had adamantinoid features. The malignancies extended well beyond the clinically discernible margins of the nevus sebaceus. Spontaneous healing of the wound o...

nevoid basal cell carcinoma syndrome (nbccs), also known as gorlin syndrome, is a hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms . the estimated prevalence varies from 1/57,000 to 1/256,000, with a male-to-female ratio of 1:1. main clinical manifestations include multiple basal cell carcinomas (bccs), odontogenic keratocysts o...

neous biopsies, yielding 69 collision tumors. Cascajo and colleagues found 54 collision tumors of malignant cutaneous neoplasms associated with seborrheic keratoses in 85,000 biopsies. The most common combinations found by Boyd and Rapini included basal cell carcinoma and nevus (14), basal cell carcinoma and seborrheic keratosis (8), nevus and seborrheic keratosis (14), actinic keratosis and ne...

The dentigerous cyst is one of the most common developmental odontogenic cysts in the jaw. Occurrence of the bilateral dentigerous cyst is uncommon, and frequently associated with syndromes like basal cell nevus syndrome or cleidocranial dysplasia. There are few reports on the presence of bilateral dentigerous cyst in nonsyndromic patients, and most of these are associated with first and third ...

GoRLiN, R. J., VICKERS, R. A., KELLN, E., and WILLIAMSON, J. J., 'Multiple basal-cell nevi syndrome. An analysis of a syndrome consisting of multiple nevoid basal-celled carcinoma, jaw cysts, skeletal anomalies, medulloblastoma, and hyporesponsiveness to parathormone', Cancer, 1965, 18, 89. HOWELL, J. B., ANDERSON, D. E., and MCCLENDON, J. L., 'The basal cell nevus syndrome', J. Am. med. Ass., ...

The hedgehog (Hh) signaling pathway plays an important role in embryogenesis across multiple species. Its activity is reduced or absent in adult organisms. However, activation of the pathway has been shown to be a factor in the development of a number of human malignancies and inhibition of the pathway is being investigated as a potential treatment for multiple cancers. The most extensively inv...