Stem cell transplantation has been performed for various diseases, contributing to a markedly improved prognosis in some cases. However, several complications, including posterior reversible encephalopathy syndrome, have been evident. Although posterior reversible encephalopathy syndrome was originally defined as a reversible disease, it has become clear that it is not reversible in all patient...

B-lymphoblastoid cell-lines may develop spontaneously in mononuclear cells from patients with multiple sclerosis, an observation rarely seen in healthy individuals. Examination of such spontaneously established B-cell lines reveal the presence of Epstein-Barr virus and retrovirus particles. We have speculated that in predisposed individuals, a dual infection with retrovirus and late acquired Ep...

14. Nonoyama, M.. and J. S. Pagano. 1971. Detection of Epstein-Barr viral genome in nonproductive cells. Nature (New Biol.) 233:103. 15. Nonoyama. M. 1975. Detection of tumor virus genomes by nucleic hybridization. Int. Rev. Exp. Pathol. 14:69. 16. Raab-Traub. N., T. Dambaugh. and E. Kieff. 1980. DNA of Epstein-Barr virus VIII. 895-8, the Prennis prototype, is an unusual deletion derivative. Ce...

OBJECTIVES To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. METHODS A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. RESULTS Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in...

Background: Breast cancer is the malignancy in humans and other mammals. Several risk factors are involved in their appearance such as higher hormone levels and obesity. Identification of a mouse mammary tumor virus supports a viral etiology for breast tumors in animals. Viruses have been implicated in the development of various cancers, but viral induction for formation breast cancer is contro...

A monoclonal antibody (mAb) designated 55H3 was produced by using chemically induced Epstein-Barr virus genome-positive B95-8 cells. mAb 55H3, which reacted with an 85- to 80-kDa polypeptide, neutralized Epstein-Barr virus-encoded DNA polymerase activity in crude extracts of chemically induced M-ABA, HR-1, and B95-8 cells, as well as the partially purified Epstein-Barr virus DNA polymerase in a...

abstract   background: multiple sclerosis (ms) is the most common autoimmune disease of central nervous system with destruction of myelin sheath mediated by auto reactive cd4+ t lymphocytes. because of the possible role of epstein-barr virus in etiology of ms and t cells immune response, the aim of this study was to evaluate anti-epstein barr virus antibodies as a marker of reactivity and produ...

BACKGROUND Acute cholestatic hepatitis without features of infectious mononucleosis is a rare presentation of primary Epstein-Barr infection, with only several cases previously reported in the medical literature. Early investigation for Epstein-Barr virus in febrile patients with deranged liver function tests and no demonstrable biliary obstruction on imaging can expedite both diagnosis and tre...

INTRODUCTION Few cases of Epstein-Barr virus myelitis have been described in the literature. Multi-centric Castleman's disease is a lymphoproliferative disorder that is well known for its associations with the human immunodeficiency virus, human herpes virus 8, and Kaposi's sarcoma. The concurrent presentation of these two diseases in a patient at the same time is extremely unusual. CASE PRES...