The purpose of this study was to evaluate whether spatial hippocampus-dependent learning is affected by the serotonergic system and stress. Therefore, 5-HTT knockout (-/-), heterozygous (+/-) and wildtype (+/+) mice were subjected to the Barnes maze (BM) and the Morris water maze (WM), the latter being discussed as more aversive. Additionally, immediate early gene (IEG) expression, hippocampal ...

BackgroundWhilst there has been progress in supportive treatment for traumatic brain injury (TBI), specific neuroprotective interventions are lacking. Models of ischaemic heart and show the therapeutic potential argon gas, but it is still not known whether inhaled (iAr) protective TBI. We tested effects acute administration iAr on oedema, tissue micro-environmental changes, neurological functio...

Gulf War Illness (GWI) is a chronic multisymptom illness with a central nervous system component that includes memory impairment as well as neurological and musculoskeletal deficits. Previous studies have shown that in the First Persian Gulf War conflict (1990-1991) exposure to Gulf War (GW) agents, such as pyridostigmine bromide (PB) and permethrin (PER), were key contributors to the etiology ...

Neuroinflammation is a key feature of Alzheimer's disease (AD), progressive neurodegenerative disorder. Microglia, the resident immune cells central nervous system, play crucial role in pathogenesis AD and are active participants neuroinflammation. Adequate reproduction neuroinflammation animal models one main methodological approaches for studying pathophysiology. The aim study was to conduct ...

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder identified by progressive loss of neurons, cognition decline, and memory deficits. The current study sought out to compare the effects scopolamine (SCO), D-galactose (D-gala), aluminium chloride (AlCl3) on performance, histological alterations hippocampus, determine best model for inducing Alzheimer’s-like disease. Twenty-fou...

Objective: Circadian rhythms are present almost in all living organisms and synchronized with the zeitgebers (time givers), especially lightdark (LD) cycles. The jetlag rotating shift work schedules lead to desynchronization of circadian clock which may cause various health problems. Studies have shown that withanolide-A (WA) is a potent nootropic neuroprotective agent found Withania somnifera....

Background: The effects of Pb-induced neurotoxicity have been largely established; however, the need for proper neuroprotective agents to mitigate remains vague. Objectives: This study aimed at investigating pre-treatment with vitexin and C. cajan extract against in Wistar rats. Methods: Twenty-four male rats were randomly assigned into four groups (n=6). control group was administered 0.5 mL d...