The synthesis of four-bar mechanisms is well understood, classical design problem. The original systematic work in this field began in the late 1800’s and continues to be an active area of research. Limitations to the classical theory of four-bar synthesis potentially limit its application to certain real-world problems by virtue of the small number of precision points and unspecified order. Th...

The mechanism by which cell and cell membrane shapes are created has long been a subject of great interest. Among the phosphoinositide-binding proteins, a group of proteins that can change the shape of membranes, in addition to the phosphoinositide-binding ability, has been found. These proteins, which contain membrane-deforming domains such as the BAR, EFC/F-BAR, and the IMD/I-BAR domains, led...

An analytical formulation for computing kinematic sensitivity of the spatial four-bar mechanism is presented. The experimental code developed is used to compute an assembled configuration for the mechanism due to a design variation. The mechanism is modeled using graph theory where a body is defined as a node and a kinematic joint is defined as an edge. The spherical joint is cut to convert the...

Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules. Amphiphysin2/BIN1 structurally stabilizes tubular formations in contrast to other N-BAR proteins involved in dynamic membrane scission processes; however, the molecular mechanism of the stabilizing effect is poorly understood. Using cryo-EM, we investigated the assemb...

This paper proposes and discusses issues on local and global text structures, all of them being connected to a lexical concept of predication. The main contributions of the present work comprise: (a) A novel functional X-bar (FX-bar) scheme is advised, aiming to reveal, model and relate the local, clause-level markers and text structures. (b) At global level, two FX-bar schemes are proposed, on...

We study the orientifold of ${\mathcal{N}} = 1$ superconformal field theories describing D3-branes probing Suspended Pinch Point singularity, as well orientifolds non-chiral obtained by a specific orbifold $\mathbb{Z}_n$ SPP. find that these models realize mechanism analogous to one recently found for complex Calabi-Yau cone over Pseudo del Pezzo surface PdP$_{3c}$: they all flow new IR fixed p...