Morphological changes in retinas of aging Fischer 344 rats were characterized. The numbers of photoreceptor cells gradually decreased as rats aged. The outer nuclear layer was 12 cells thick at 3 months, but was reduced to less than 8 cells by 18 months. The decrease of photoreceptor cells was more pronounced in rats housed under a light intensity of 32-ft-c than in rats housed under a light in...

The inherited macular dystrophies comprise a heterogeneous group of disorders characterised by central visual loss and atrophy of the macula and underlying retinal pigment epithelium (RPE). The different forms of macular degeneration encompass a wide range of clinical, psychophysical and histological findings. The complexity of the molecular basis of monogenic macular disease is now beginning t...

Purpose: Describe the outcomes of thermal laser photocoagulation in three cases of retinal pigment epithelium detachment associated to age-related macular degeneration. Methods: Three patients with avascular retinal pigment epithelium detachment were treated with green diode laser photocoagulation. Mild macular grid laser application, similar to the treatment of diabetic macular edema was perfo...

In a previous study (Le Gros Clark and Warwick, 1946) the degeneration of olfactory receptors in the rabbit following complete or partial ablation of the olfactory bulb was examined by reference to sections of the mucosa covering the septal cartilage, stained by Bodian's protargol method. Evidence was advanced to show that this is a true secondary degeneration following interruption of the prim...

Retinal degeneration was induced by a single intraperitoneal injection of N-methyl-N-nitrosourea in female Sprague-Dawley albino rats at 50 days of age by two dose regimens, which were observed sequentially at 24, 48, and 72 hours and 7, 21, and 35 days after the treatment. After a dose of 75 mg/kg, methylnitrosourea evoked progressive retinal degeneration in all treated rats whereas a dose of ...

Background: Anti-tuberculosis drugs-induced hepatotoxicity is associated with oxidative stress. Curcumin a powerful antioxidant and has been found to protect the liver from damaging effects of The study aimed assess curative protective against induced by anti TB- drugs (Isoniazid-Rifampicin) using an experimental model Albino rabbits. Methods: rabbits(n=24) were divided into four groups. Group ...

Abstract Concor is a beta-blocker drug used to treat high blood pressure, acute coronary syndrome, and control the rapid pulse of heart such as atrial fibrillation. Some its adverse effects include hepatitis, increased triglycerides liver enzymes. Monitoring kidney functions in patients with hepatic or renal impairment who are taking concor recommended. The current study was undertaken define w...

: This narrative review highlights routes of ocular drug delivery for age-related macular degeneration (AMD). AMD is the leading cause irreversible blindness in industrialized countries and accounts 8.7% worldwide. Advanced can be classified into two subtypes: late-stage dry [known as geographic atrophy (GA)] neovascular (nAMD). GA often bilateral results from progressive loss photoreceptors ar...

PURPOSE To compare optical coherence tomography (OCT) and histology of outer retinal tubulation (ORT) secondary to advanced age-related macular degeneration in patients and in postmortem specimens, with particular attention to the basis of the hyperreflective border of ORT. METHOD A private referral practice (imaging) and an academic research laboratory (histology) collaborated on two retrosp...