Part of the cellular and physiological functions of BAG-1 (Bcl-2-associated athanogene 1) has been ascribed to the ability of this hsp70 (heat-shock protein 70) co-chaperone to regulate steroid receptor activity. BAG-1 has been reported to inhibit the GR (glucocorticoid receptor) and stimulate the androgen receptor, but to leave the activity of the MR (mineralocorticoid receptor) unchanged. Giv...

PURPOSE The estimated microbial contamination rate for complex, multiple-step, medium-risk-level compounding was studied. METHODS The results of evaluations of the aseptic technique of pharmacists and technicians in compounding complex USP medium-risk-level sterile preparations were compiled to estimate the microbial contamination rate. The testing took place in 2002 and 2003 at a single inst...

Aesculin hydrolysis (ESC) is one of the key reactions in differentiating pathogenic Yersinia enterocolitica biotypes 1B, 2, 3, 4 and 5 from the less-pathogenic biotype 1A. Because the ESC reaction is caused by β-glucosidase (βGLU) activity of the bacteria, we studied whether two commonly used methods (BBL CHROMagar Orientation and Vitek2 Gram-negative identification card) could be used in asses...

Representative strains of anaerobic bacteria from human infections were used to evaluate broth media, gas mixtures, and inocula for use in developing a procedure for performing minimal inhibitory concentration antimicrobic susceptibility tests. Nine commercially available media, including two that were chemically defined, were tested. Tests were performed in atmospheres with carbon dioxide conc...

The bag cells (BC) of Aplysia are a group of peptidergic neurons that respond to brief electrical stimulation by producing a prolonged afterdischarge of synchronous action potentials. We have demonstrated previously that the cyclic nucleotide, cyclic 3’:5’-adenosine monophosphate (cyclic AMP), plays a role in the genesis of the bag cell afterdischarge and that the microinjection of the catalyti...

purpose: to report a case of capsular bag distension syndrome (cbds) with solid material presenting eight years after cataract surgery. case report: a 58-years-old female who underwent an uneventful clear-cornea phacoemulsification with in-the-bag intraocular lens (iol) implantation in the right eye, presented with a chief complaint of blurred vision (va: 20/200) and cobweb like matter appearin...

BAG-1 is a multifunctional protein that blocks apoptosis and interacts with several types of proteins, including Bcl-2 family proteins, the kinase Raf-1, certain tyrosine kinase growth factor receptors, and steroid hor mone receptors, possibly by virtue of its ability to regulate the Hsp70/ Hsc70 family of molecular chaperones. Two major forms of the human and mouse BAG-1 proteins were detected...

Between April and December 1994, 23 blood cultures from human immunodeficiency virus-infected patients grew rapidly growing mycobacteria suspected to be Mycobacterium chelonae at a hospital in New Jersey. The isolates were later identified as M. abscessus. Several bacterial species, including M. abscessus, were cultured from an opened multidose supplement vial (BBL Septi-Chek AFB Supplement) th...

The physicochemical conditions of high-rate algal ponds were responsible for a more than 97% reduction in the infectivity of Cryptosporidium parvum oocysts in neonatal mice. The use of semipermeable bags of cellulose showed that pH, ammonia, and/or light seems to be a major factor for the inactivation of oocysts in wastewater, supporting the importance of alga-based systems for safer reuse of t...

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