background: factor viii inhibitor is one of the most problems in the treatment of hemophilia. patients with hemophilia who have inhibitors are capable of severe hemorrhage and treatments of these patients are more expensive and more difficult than those patients without inhibitor. the aim of present study was to determine the prevalence of inhibitor and to assess the necessity of screening of t...

The alkaline proteinase from the mesophilic bacterium Bacillus mesentericus has been crystallized in a 1:1 complex with the inhibitor eglin-C from the medical leech. The crystals have cell dimensions of a = 43.0, b = 71.9, c = 48.3 A and beta = 110.0 degrees and are in the space group P2(1). Three-dimensional data to 2.0 A have been recorded on film from a single crystal. The orientation and po...

Acinetobacter baumannii is a highly antimicrobial resistant nosocomial pathogen. Resistance to currently used antibiotics has limited effective drugs against this bacterium. This study aimed propose rational inhibitor design the LpxA protein of A. using virtual screening method based on similar structure ligands. In study, we targeted protein, which involved in early stage LPS biosynthesis. nex...

the bacterium oceanimonas sp. (o. sp.) gk1 is a member of the aeromonadaceae family and its genome represents several virulence genes involved in fish and human pathogenicity. in this original research study we aimed to identify and characterize the putative virulence factors and pathogenicity of this halotolerant marine bacterium using genome wide analysis. materials and methods: the genome da...

Background: Inhibitory antibody to exogenous Factor VIII (FVIII) is a major complication of hemophilia treatment. This study was conducted to determine the prevalence of inhibitor antibody directed against FVIII.Methods: From May 2010 to May 2011, 52 patients with severe hemophilia A admitted in Amirkola Children’s Hospital were evaluated. Those who had abnormal mixing study, antibody against F...

Rho-dependent termination of transcription (RDTT) is a critical regulatory mechanism specific to bacteria. In subset species including most Actinobacteria and Bacteroidetes, the Rho factor contains large, poorly conserved N-terminal insertion domain (NID) cryptic function. To date, only two NID-bearing factors from high G + C have been thoroughly characterized. Both can trigger RDTT at promoter...

Abstract The marine bacterium Vibrio parahaemolyticus is the leading cause of seafood-related food poisoning worldwide and a pathogen species harvested in aquaculture. An outbreak pathogenic V. within crustacean bi-valve aquaculture facilities often results significant loss farmed product spread into human population. Evidence shows several bacteria microalgae have antibacterial effects against...