objective: the present study was carried out to determine the most potent available antimicrobials in the treatment of pathogens of reproductive health importance in nigeria. material and methods: using the agar disc-diffusion and modified agar well-diffusion methods, bacterial and fungal pathogens obtained from clinical specimens of female patients presenting at the university college hospital...

The aim of this study was to investigate the effect of sodium dodecyl sulfate (SDS), citric acid, and hydrogen peroxide (H2O2), alone or in combination, on reducing the population of four foodborne pathogens, including Escherichia coli, Listeria monocytogenes, Salmonella typhimurium, and Staphylococcus aureus on eggshells. In each series of tests, eight fresh eggs were inoculated with each bact...

Severe bacterial infection remains one of the major causes of newborn deaths in low-income countries. A key challenge for reducing this burden is making definitive treatment more easily available. Active case detection through early postnatal home visits can work under trial conditions but is difficult to implement at scale under routine conditions. In many settings, making treatment available ...

BACKGROUND The timing and indications for surgical intervention to prevent systemic embolism in infective endocarditis (IE) remain controversial. This trial compares clinical outcomes of early surgery and conventional treatment in patients with IE. METHODS RESULTS Thirty-seven patients were assigned to the early-surgery group (<48 hours), whereas 39 were assigned to conventional therapy. Of t...

OBJECTIVE To investigate parents' views about deferred consent to inform management of trial disclosure after a child's death. METHODS A postal questionnaire survey was sent to members of the Meningitis Research Foundation UK charity, whose child had suffered from bacterial meningitis or meningococcal septicaemia within the previous 5 years. Main outcome measures were acceptability of deferre...

The effect of low-dose antigen exposure on the development of immunity to Helicobacter pylori infection was studied in outbred mice. Animals that were primed with a subinfectious number of H. pylori bacteria exhibited significantly lower bacterial loads after challenge with an infectious dose of pathogen (versus controls, P < 0.05).

Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (MAIVF) is one of the rare complications of infective endocarditis. Echocardiography plays an important role in the diagnosis of this condition. Transesophageal echocardiography (TEE) is generally superior to the transthoracic approach in the evaluation of the complications resulting from infective endocarditis. In this report, we discus...

BACKGROUND This study aimed to evaluate the efficacy of combined vancomycin and steroid therapy for the treatment of culture-proven bacterial meningitis in pediatric patients. MATERIALS AND METHODS We identified a total of 86 pediatric patients with culture-positive cerebrospinal fluid who were treated at our facility between 2005 and 2015. Ten of these patients (5 boys and 5 girls) received ...

Some new 2-alkyl-5-mercapto-1,3,4-Oxadiazoles and 3-alkyl-5-mercapto-1,2,3-4H triazoles were synthesized from hydrazides of acid oil and oil recovered from spent bleaching earth. These newly synthesized compounds were characterized on the basis of elemental analysis and evaluated for biological properties. Certain derivatives exhibited fairly high antibacterial and antifungal activities when co...

Helicobacter cinaedi is an infrequent, but well recognized cause of gastroenteritis in immunosuppressed patients. Here we report a case of an extra-intestinal infection in a previous healthy 61-year old heterosexual male. Focus for the infection was most likely cellulitis on the lower right leg. The bacterium was cultured from blood twice within one week. Electron microscopy of the isolate visu...