Bacterial translocation as a direct cause of sepsis is an attractive hypothesis that presupposes that in specific situations bacteria cross the intestinal barrier, enter the systemic circulation, and cause a systemic inflammatory response syndrome. Critically ill children are at increased risk for bacterial translocation, particularly in the early postnatal age. Predisposing factors include int...

The development of systemic inflammation, acute lung injury, and multiple organ failure after a major thermal injury, as well as nonthermal forms of trauma, remain relatively common causes of morbidity and mortality. During the past two decades, increasing recognition that the ischemic gut may contribute to the development of sepsis and organ failure in burn patients, as well as other criticall...

The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme beta-lactamase or active eff...

Abstract Bacterial meningitis is a serious infection of the central nervous system that affects people all over world. Streptococcus pneumoniae and Neisseria meningitidis are most common pathogens causing meningeal inflammation in Europe. Treatment with standard antibiotics becoming ineffective, not only due to their inability cross blood-brain barrier, but also rising antibiotic resistance. As...

Underproduction of hydrochloric acid into the stomach is frequently encountered in subjects from developing countries. We explore the hypothesis that hypochlorhydria compromises the gastric barrier and favours bacterial overgrowth in the proximal parts of the small intestine where nutrient absorption takes place. Food calories are thus deviated into bacterial metabolism. In addition to an adequ...

Previously, we showed that rhinovirus (RV), which is responsible for the majority of common colds, disrupts airway epithelial barrier function, as evidenced by reduced transepithelial resistance (R(T)), dissociation of zona occludins 1 (ZO-1) from the tight junction complex, and bacterial transmigration across polarized cells. We also showed that RV replication is required for barrier function ...

Increased vascular endothelial permeability and inflammation are major pathological mechanisms of pulmonary edema and its life-threatening complication, the acute respiratory distress syndrome (ARDS). We have previously described potent protective effects of hepatocyte growth factor (HGF) against thrombin-induced hyperpermeability and identified the Rac pathway as a key mechanism of HGF-mediate...

Anti-bacterial drugs have “selective toxicity”, that is they interact with a target present on the bacterial cell, the prokaryote, that is not present in the mammalian host, the eukaryote. For the ß-lactam drugs, this target is the cell wall. Mammalian cells lack cell walls, which for the bacteria are a critically important barrier protecting the organism from not only the vagaries of osmotic s...

Background: Our previous reports found that abdominal paracentesis drainage (APD) benefits the clinical outcome in patients with severe acute pancreatitis (SAP). However, the effect of APD on SAP-associated intestinal injury remains unclear. Objective: We aimed to determine whether APD could attenuate intestinal barrier dysfunction and bacterial translocation in rats with SAP. Methods: Sprague-...

Solanum melongena is susceptible to diverse diseases and parasites, in particular the wilts (bacterial, Fusarium Verticillium), nematodes, some insects. torvum robust Verticillium bacterial root-knot nematode. It was reported that interspecific hybrid plants originated out of hybridization these species were sterile. In our previous studies have been carried overcome this barrier, only from Fas...