نتایج جستجو برای: background major histocompatibility complex mhc comprises a group of genes
تعداد نتایج: 23367723 فیلتر نتایج به سال:
this research was conducted to examine the effect of a concurrent training on rest level of leptin of plasma and some hormonal factors in non-athlete subjects. the research population included non-athlete men who didn’t participate in any organized sport activities. 30 men were chosen voluntarily among the above-mentioned population and were divided into 2 groups: experimental (15 subjects) an...
The major histocompatibility complex (MHC) is a multi-copy immune gene family in vertebrates. Its genes are highly variable and code for antigen-presenting molecules. Characterization of MHC different species investigating the mechanisms that shape diversity an important goal understanding evolution biological diversity. Here we developed next-generation sequencing (NGS) protocol to genotype cl...
In the fifty years since the rules of histocompatibility were first established, the major histocompatibility complex (MHC) has become one of the most intensively studied regions of the vertebrate genome. Therefore, it seems rather odd that one of the first questions posed at a recent workshop on MHC evolution was ‘what exactly is the MHC?’ Nevertheless, the question was astute because it encom...
Genes of the major histocompatibility complex (MHC) are crucial for adaptive immunity, and theory predicts that optimal number alleles is intermediate rather than maximal. Support such an optimum in MHC allele count has mainly been demonstrated studies on parasite load reproductive traits. In this study we tested if class II (MHCII) based positively selected sites was correlated with increased ...
Peptides that bind to a given major histocompatibility complex (MHC) molecule share sequence similarity. Therefore, a position specific scoring matrix (PSSM) or profile derived from a set of peptides known to bind to a specific MHC molecule would be a suitable predictor of whether other peptides might bind, thus anticipating possible T-cell epitopes within a protein. In this approach, the bindi...
CD8(+) CTLs are essential for effective immune defense against intracellular microbes and neoplasia. CTLs recognize short peptide fragments presented in association with MHC class I (MHCI) molecules on the surface of infected or dysregulated cells. Ag recognition involves the binding of both TCR and CD8 coreceptor to a single ligand (peptide MHCI [pMHCI]). The TCR/pMHCI interaction confers Ag s...
Classical CD4(+) and CD8(+) T cells recognize Ag presented by MHC class II (MHCII) and MHC class I (MHCI), respectively. However, our results show that CD4(-/-) mice mount a strong, readily detectable CD8(+) T cell response to MHCII-restricted epitopes after a primary bacterial or viral infection. These MHCII-restricted CD8(+)CD4(-) T cells are more similar to classical CD8(+) T cells than to C...
Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II be...
Major histocompatibility complex (MHC) class II combined immunodeficiency (CID), also known as type II bare lymphocyte syndrome, is an autosomal recessive genetic disorder characterized by the complete lack of expression of MHC class II antigens. The defect results from a coordinated lack of transcription of all class II genes. Cell fusion studies using many patient- and experimentally derived ...
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