نتایج جستجو برای: b and t lymphocyte attenuator
تعداد نتایج: 17065848 فیلتر نتایج به سال:
The functions of bone marrow plasma cells (BMPC) beyond antibody production are not fully elucidated and distinct subsets BMPC suggest potential different functions. Phenotypic differences were identified for human depending on CD19 expression. Since is a co-stimulatory molecule the B-cell-receptor (BCR), IgA + IgM express BCR their surface, we here studied whether expression affects cellular r...
Vγ9Vδ2 T cells, the major subset of the human peripheral blood γδ T-cell, respond to microbial infection and stressed cells through the recognition of phosphoantigens. In contrast to the growing knowledge of antigen-mediated activation mechanisms, the antigen-independent and cytokine-mediated activation mechanisms of Vγ9Vδ2 T cells are poorly understood. Here, we show that interleukin (IL) -12 ...
B and T-lymphocyte attenuator (BTLA) plays an immunosuppressive role by inhibiting T- B-cell functions. BTLA is associated with a variety of diseases, especially cancer immunity. However, the function in various cancers its clinical prognostic value have still not been comprehensively analyzed. This study aimed to identify relationship between from perspectives differences expression, value, im...
The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvironment marked by exacerbated lymphoid stroma activation and increased recruit...
Therapy with immune checkpoint inhibitors (ICIs) can lead to durable tumor control in patients various advanced stage malignancies. However, this is not the case for all patients, leading an ongoing search biomarkers predicting response and outcome ICI. The B T lymphocyte attenuator (BTLA) expressed on cells that was shown modulate therapeutic responses. Here, we evaluate circulating levels of ...
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