an efficient one-pot three-component procedure for the synthesis of new chiral spiro-oxindolopyrrolizidines with highly regio-, diastereo-, and enantioselective from 1,3-dipolar cycloaddition of azomethine ylides and optically pure active cinamoyl oxazolidinone are described. the process occurs at room temperature in aqueous ethanol as green solvent and in the absence of any bidentate chelating...

Pyrrolidines are intriguing scaffolds that can be found in a variety of natural products. They have numerous biological and organocatalytic uses. The asymmetric [3+2] cycloadditions employing metal catalysis with suitable chiral ligands is robust method for the synthesis enantioenriched pyrrolidines up to four centres. Recent advances summarized Review by Guiry Kumar (DOI. 10.1002/chem.20230029...

The development of multicomponent reactions (MCRs) designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. A comparative study of the synthesis of new bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) ring systems by the cycloaddition of azomethine ylides generated by a decarboxylative route from sarc...