نتایج جستجو برای: azoles

تعداد نتایج: 1992  

Journal: :Revista chilena de infectología 2020

Journal: :Journal of Synthetic Organic Chemistry, Japan 1968

Journal: :Acta dermatovenerologica Alpina, Pannonica, et Adriatica 2015
Andraž Dovnik Andrej Golle Dušan Novak Darja Arko Iztok Takač

Vulvovaginal candidiasis (VVC) affects around three-quarters of all women during their reproductive age, although the exact incidence of VVC is difficult to determine because many patients are self-treated. The infections are divided into complicated and uncomplicated. Uncomplicated VVC is most effectively treated with local azoles. Oral treatment with a single dose of fluconazole is also effec...

2010
Nam Kyun Kim Kyunghwan Han Won Hee Jung

Azoles are currently the most widely used class of antifungal drugs clinically, and are effective for treating fungal infections. Target site of azoles is ergosterol biosynthesis in fungal cell membrane, which is absent in the mammalian host. However, the development of resistance to azole treatments in the fungal pathogen has become a significant challenge. Here, we report the identification a...

Journal: :Acta Crystallographica Section A Foundations and Advances 2019

Journal: :Antimicrobial agents and chemotherapy 1998
E K Manavathu J L Cutright P H Chandrasekar

We investigated the antifungal activities of itraconazole and voriconazole on Aspergillus species by time kill studies, and the results were compared with those obtained for Candida species. Exposure of Aspergillus fumigatus conidia to varying concentrations (1.25 to 10 microg/ml) of itraconazole and voriconazole resulted in cellular death; the cytocidal effect was time and concentration depend...

2016
Alia A. Sagatova Mikhail V. Keniya Rajni K. Wilson Manya Sabherwal Joel D. A. Tyndall Brian C. Monk

Emergence of fungal strains showing resistance to triazole drugs can make treatment of fungal disease problematic. Triazole resistance can arise due to single mutations in the drug target lanosterol 14α-demethylase (Erg11p/CYP51). We have determined how commonly occurring single site mutations in pathogenic fungi affect triazole binding using Saccharomyces cerevisiae Erg11p (ScErg11p) as a targ...

Journal: :Journal of the American Podiatric Medical Association 2015
Mahmoud Ghannoum

Azole antifungal agents (eg, fluconazole and itraconazole) have been widely used to treat superficial fungal infections caused by dermatophytes and, unlike the allylamines (such as terbinafine and naftifine), have been associated with resistance development. Although many published manuscripts describe resistance to azoles among yeast and molds, reports describing resistance of dermatophytes ar...

Journal: :Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2011
Gordon Ramage Anto Jose Brent Coco Ranjith Rajendran Riina Rautemaa Colin Murray David F Lappin Jeremy Bagg

OBJECTIVE The aim of this study was to evaluate and compare the activity of prescription and over-the-counter antimicrobial compounds against planktonic and biofilm forms of Candida albicans isolated from cases of oral candidiasis in vitro. STUDY DESIGN The efficacy of azoles, polyenes, an echinocandin, and 4 over-the-counter mouthwashes were tested against C. albicans-derived planktonic and ...

2009
sanjay Pujari

need treatment with intravenous amphotericin B. However this is used only when there has been a poor response to full doses of azoles, e.g. 800 mg/day of fluconazole. For EC or oral intravenous azole therapy and in unresponsive infections, amphotericin B may be used. The frequency of EC as a cause of esophageal symptoms is so high that an empirical course of fluconazole is recommend for all pat...

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