DESCRIPTION AUGMENTIN is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Amoxicillin is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acid. The amoxicillin molecular formula is C16H19N3O5S•3H2O, and the molecular weight ...

cis-3-Acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones were prepared through a Staudinger [2+2]-cyclocondensation between acetoxyketene and the appropriate epoxyimines in a highly diastereoselective way. Subsequent potassium carbonate-mediated acetate hydrolysis, followed by intramolecular ring closure through epoxide ring opening, afforded stereodefined 3-aryl-4-hydroxy-2-oxa-6-azabicyclo[3.2.0]he...

IR and Raman spectra and phase transitions have been studied on various salts of azabicyclo[2.2.2]octane (ABCO) and l,4-diazabicyclo[2.2.2]octane (DABCO) which forms with simple strong acids adducts of 2 : 1, 1 : 1 and 1 : 2 composition. Only 2 : 1 DABCO adducts form homoconjugated cations containing [NH · · · H]+ hy. drogen bonds close to symmetrical ones, showing broad absorption in the low f...

Several novel tricyclic compounds with a unique amine moiety (1, 2a--i) were designed and prepared based on the structure of triperiden for the development of anti-influenza virus agents. An in vitro antiviral assay showed that 1-(1-azabicyclo[3.3.0]octan-5-yl)-1-(4-fluorophenyl)-1-(2-tricyclo[3.3.1.1(3.7)]decyl)methan-1-ol hydrochloride (2f) has a potent anti-influenza A virus activity. Furthe...

Two new carbapenem antibiotics, carpetimycins C and D have been isolated from the culture broth of Streptomyces p. KC-6643, which produced carpetimycins A and B. The structures of carpetimycins C and D have been determined to be (5R,6R)-3-[2-acetamidoethyl(R)-sulfinyl]-6-(1-hydroxy-l-methylethyl)-7-oxo-l-azabicyclo[3.2.0]hept-2-ene-2-carboxylic a id and (5R,6R)-3-[2-acetamidoethyl-(R)-sulfinyl]...