PURPOSE To investigate the association between ocular biometrics such as axial length (AL), anterior chamber depth (ACD), lens thickness (LT), vitreous chamber depth (VCD) and corneal power (CP) with different refractive errors. METHODS In a cross-sectional study on the 40 to 64-year-old population of Shahroud, random cluster sampling was performed. Ocular biometrics were measured using the A...

PURPOSE To explore the possible influence of ocular growth, refractive error and age on the crystalline lens in school-age children. METHODS A Taiwan nationwide survey of myopia performed in 2006 was used to determine the prevalence and severity of myopia and the changes in ocular components. A total of 11,656 students were enrolled, including 5,390 boys and 6,266 girls, with ages ranging fro...

PURPOSE Central corneal curvature is known to vary with refractive error, but the relation between corneal topography and ametropia is less clear. The current study was conducted to determine whether a relation exists between corneal asphericity and myopia. Associations between corneal asphericity and each of the components of refraction also were examined. METHODS Corneal asphericity and api...

PURPOSE To determine whether ciliary body thickness (CBT) is related to refractive error in school-age children. METHODS Fifty-three children, 8 to 15 years of age, were recruited. CBT was measured from anterior segment OCT images (Visante; Carl Zeiss Meditec, Inc., Dublin, CA) at 1 (CBT1), 2 (CBT2) and 3 (CBT3) mm posterior to the scleral spur. Cycloplegic refractive error was measured with ...

OBJECTIVE To examine genetic influences for quantitative refraction. Spherical equivalent and its related binary traits of myopia and hyperopia are highly correlated within families. Many linkage regions have been reported for myopia, high myopia, and quantitative refraction. However, the measured phenotype of spherical equivalent is in large part dictated by the relationship between the underl...

PURPOSE Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population. METHODS High myopia is defined by a spherical equivalent of less than or equal to -6.00 diopter sp...

BACKGROUND To determine the influences of myopia and optic disc size on ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thickness profiles obtained by spectral domain optical coherence tomography (OCT). METHODS One hundred and sixty-eight eyes of 168 young myopic subjects were recruited and assigned to one of three groups according to their spher...

To investigate the effects of collagen cross-linking using glyceraldehyde on the biomechanical properties of the sclera and the axial elongation of form-deprived myopia in the guinea pig. Thirty-six guinea pigs were randomly assigned to four groups: FDM (form-deprived myopia); FDMG (form-deprived myopia treated with glyceraldehyde); FDMS (form-deprived myopia treated with 0.9% isotonic sodium c...

Purpose: To study the correlation between macular thickness and different grades of myopia in their axial length and spherical equivalent refraction.

PURPOSE EGR1 (OMIM 128990) is an early growth response gene that has been shown to be related to myopia by upregulation and down-regulation of axial eye growth in experimentally induced chicken myopia and knockout mice. The purpose of this study was to test whether variations in the human EGR1 gene are related to high myopia. METHODS Genomic DNA was prepared from leukocytes of peripheral bloo...